Seroatlas · Human Serome Atlas

NKG7

Protein NKG7

Also known as: GIG1, GMP-17, NKG7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16617
Gene
NKG7
Ensembl
ENSG00000105374
Chromosome
19
Canonical length
165 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Involved in defense response to protozoan. Located in cytolytic granule membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>Q16617|NKG7
     1  MELCRSLALL GGSLGLMFCL IALSTDFWFE AVGPTHSAHS GLWPTGHGDI ISGYIHVTQT
    61  FSIMAVLWAL VSVSFLVLSC FPSLFPPGHG PLVSTTAAFA AAISMVVAMA VYTSERWDQP
   121  PHPQIQTFFS WSFYLGWVSA ILLLCTGALS LGAHCGGPRP GYETL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKG7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
568 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 568 nTPM
  • spleen: 161 nTPM
  • lymph node: 128 nTPM
  • lung: 51 nTPM
  • liver: 25 nTPM
  • appendix: 22 nTPM

Single-cell type

  • nk-cells: 2,044 nCPM
  • t-cells: 527 nCPM
  • neutrophil progenitors: 376 nCPM
  • monocyte progenitors: 233 nCPM
  • monocytes: 57 nCPM
  • innate lymphoid cells: 35 nCPM

Immune cell

  • gdT-cell: 6,845 nTPM
  • total PBMC: 4,935 nTPM
  • NK-cell: 4,809 nTPM
  • memory CD8 T-cell: 4,296 nTPM
  • naive CD8 T-cell: 3,124 nTPM
  • MAIT T-cell: 2,878 nTPM

Brain region

  • medulla oblongata: 4.5 nTPM
  • thalamus: 3.8 nTPM
  • white matter: 3.3 nTPM
  • choroid plexus: 3.2 nTPM
  • pons: 3.2 nTPM
  • spinal cord: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0
gnomAD missense Z
0.03
DepMap mean gene effect
0.18
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKG7 as an antibody target. Whether an autoantibody or antibody against NKG7 could matter depends on whether native NKG7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKG7 is annotated at the cell surface, where native NKG7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NKG7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NKG7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...