Seroatlas · Human Serome Atlas

NIBAN1

Protein Niban 1

Also known as: C1orf24, FAM129A, GIG39, NIBA1_HUMAN, NIBAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZQ8
Gene: NIBAN1
Ensembl: ENSG00000135842
Chromosome: 1
Canonical length: 928 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the family with sequence similarity 129 protein family. This gene is highly expressed in several cancer cells and may serve as a prognostic marker for certain cancers. The encoded protein may play a role in regulating p53-mediated apoptosis. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

928 residues, UniProt reviewed canonical sequence.

>Q9BZQ8|NIBAN1
     1  MGGSASSQLD EGKCAYIRGK TEAAIKNFSP YYSRQYSVAF CNHVRTEVEQ QRDLTSQFLK
    61  TKPPLAPGTI LYEAELSQFS EDIKKWKERY VVVKNDYAVE SYENKEAYQR GAAPKCRILP
   121  AGGKVLTSED EYNLLSDRHF PDPLASSEKE NTQPFVVLPK EFPVYLWQPF FRHGYFCFHE
   181  AADQKRFSAL LSDCVRHLNH DYMKQMTFEA QAFLEAVQFF RQEKGHYGSW EMITGDEIQI
   241  LSNLVMEELL PTLQTDLLPK MKGKKNDRKR TWLGLLEEAY TLVQHQVSEG LSALKEECRA
   301  LTKGLEGTIR SDMDQIVNSK NYLIGKIKAM VAQPAEKSCL ESVQPFLASI LEELMGPVSS
   361  GFSEVRVLFE KEVNEVSQNF QTTKDSVQLK EHLDRLMNLP LHSVKMEPCY TKVNLLHERL
   421  QDLKSRFRFP HIDLVVQRTQ NYMQELMENA VFTFEQLLSP HLQGEASKTA VAIEKVKLRV
   481  LKQYDYDSST IRKKIFQEAL VQITLPTVQK ALASTCKPEL QKYEQFIFAD HTNMIHVENV
   541  YEEILHQILL DETLKVIKEA AILKKHNLFE DNMALPSESV SSLTDLKPPT GSNQASPARR
   601  ASAILPGVLG SETLSNEVFQ ESEEEKQPEV PSSLAKGESL SLPGPSPPPD GTEQVIISRV
   661  DDPVVNPVAT EDTAGLPGTC SSELEFGGTL EDEEPAQEEP EPITASGSLK ALRKLLTASV
   721  EVPVDSAPVM EEDTNGESHV PQENEEEEEK EPSQAAAIHP DNCEESEVSE REAQPPCPEA
   781  HGEELGGFPE VGSPASPPAS GGLTEEPLGP MEGELPGEAC TLTAHEGRGG KCTEEGDASQ
   841  QEGCTLGSDP ICLSESQVSE EQEEMGGQSS AAQATASVNA EEIKVARIHE CQWVVEDAPN
   901  PDVLLSHKDD VKEGEGGQES FPELPSEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIBAN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 154 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 154 nTPM
urinary bladder: 103 nTPM
colon: 97 nTPM
blood vessel: 95 nTPM
salivary gland: 95 nTPM
pancreas: 81 nTPM

Single-cell type

neutrophils: 4,383 nCPM
smooth muscle cells: 873 nCPM
t-cells: 766 nCPM
salivary acinar cells: 638 nCPM
cardiomyocytes: 582 nCPM
lacrimal acinar cells: 572 nCPM

Immune cell

neutrophil: 72 nTPM
basophil: 21 nTPM
T-reg: 12 nTPM
eosinophil: 11 nTPM
NK-cell: 5.7 nTPM
myeloid DC: 5.2 nTPM

Brain region

medulla oblongata: 7.7 nTPM
white matter: 6.2 nTPM
choroid plexus: 6 nTPM
spinal cord: 5.5 nTPM
pons: 4.8 nTPM
cerebral cortex: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NIBAN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIBAN1 as an antibody target. Whether an autoantibody or antibody against NIBAN1 could matter depends on whether native NIBAN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIBAN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NIBAN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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