Seroatlas · Human Serome Atlas

NHLRC2

NHL repeat-containing protein 2

Also known as: DKFZp779F115, FLJ20147, FLJ25621, FLJ33312, MGC45492, NHLC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBF2
Gene: NHLRC2
Ensembl: ENSG00000196865
Chromosome: 10
Canonical length: 726 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

726 residues, UniProt reviewed canonical sequence.

>Q8NBF2|NHLRC2
     1  MAAPGGRGRS LSGLLPAQTS LEYALLDAVT QQEKDSLVYQ YLQKVDGWEQ DLSVPEFPEG
    61  LEWLNTEEPI SVYKDLCGKI VVLDFFTYCC INCIHLLPDL HALEHTYSDK DGLLIIGVHS
   121  AKFPNEKVLD NIKSAVLRYN ITHPMVNDAD ASLWQELEVS CWPTLVILGP RGNMLFSLIG
   181  EGHKDKLFLY TSIALKYYKD RGQIRDNKIG IKLYKDSLPP SPLLFPGKVT VDQVTDRLVI
   241  ADTGHHRILV VWKNGQIQYS IGGPNPGRKD GIFSESTFNS PQGVAIMNNI IYVADTENHL
   301  IRKIDLEAEK VSTVAGIGIQ GTDKEGGAKG EQQPISSPWD VVFGTSGSEV QRGDILWIAM
   361  AGTHQIWALL LDSGKLPKKN ELTKGTCLRF AGSGNEENRN NAYPHKAGFA QPSGLSLASE
   421  DPWSCLFVAD SESSTVRTVS LKDGAVKHLV GGERDPMNLF AFGDVDGVGI NAKLQHPLGV
   481  TWDKKRNLLY VADSYNHKIK VVDPKTKNCT TLAGTGDTNN VTSSSFTEST FNEPGGLCIG
   541  ENGELLYVAD TNNHQIKVMD LETKMVSVLP IFRSENAVVD GPFLVEKQKT LPKLPKSAPS
   601  IRLSPVTACA GQTLQFKLRL DLPSGSKLTE GVSSCWFLTA EGNEWLLQGQ IAAGDIENIS
   661  SQPTISLQIP DDCLSLEAIV SVSVFLYYCS ADSSACMMKA ILFSQPLQIT DTQQGCIAPV
   721  ELRYVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NHLRC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 15 nTPM
skeletal muscle: 9.9 nTPM
parathyroid gland: 9.8 nTPM
retina: 9.4 nTPM
prostate: 8.3 nTPM
liver: 8.1 nTPM

Single-cell type

cardiomyocytes: 297 nCPM
myonuclei: 183 nCPM
prostatic glandular cells: 133 nCPM
choroid plexus epithelial cells: 120 nCPM
pituicytes/fscs: 117 nCPM
sertoli cells: 113 nCPM

Immune cell

non-classical monocyte: 0.9 nTPM
basophil: 0.8 nTPM
plasmacytoid DC: 0.8 nTPM
eosinophil: 0.7 nTPM
memory CD8 T-cell: 0.7 nTPM
gdT-cell: 0.6 nTPM

Brain region

choroid plexus: 23 nTPM
white matter: 19 nTPM
cerebellum: 18 nTPM
medulla oblongata: 18 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NHLRC2.

Disease | AllUniProt

Conditions NHLRC2 is implicated in, by any mechanism.

Fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA) MIM:618278

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 132 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Fibrosis, neurodegeneration, and cerebral angiomatosis
Melanoma
See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 0.74
DepMap mean gene effect: -0.64
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NHLRC2 as an antibody target. Whether an autoantibody or antibody against NHLRC2 could matter depends on whether native NHLRC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NHLRC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NHLRC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...