NFXL1

Protein identityUniProt · HPA

UniProt accession

Q6ZNB6

Gene

NFXL1

Ensembl

ENSG00000170448

Chromosome

4

Canonical length

911 aa

Protein class

Predicted membrane proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

911 residues, UniProt reviewed canonical sequence.

>Q6ZNB6|NFXL1
     1  MEASWRQVAG GRGRSRGRAT AAPSGNGVHL RGAGGGREKG SVGAVPSGTS PGGVATTAAA
    61  GSRHSPAGSQ ALQTTAASEL MSQKKFEEIK KANQAAARKL VEEQFSSSSE EGDEDFEGKQ
   121  GKILANTFIT YTTQTDGDTR ELERTKQYVN EAFQAGAMTC LICIASVKRN QAVWSCSGCF
   181  CIFHMPCIQK WAKDSQFLVS SVTDDDFGKK DCPWPCPKCR FEYKRSETPS RYYCYCGKVE
   241  DPPLDPWLVP HSCGQVCERE FKPPCGHKCL LLCHPGPCPP CPKMVTTTCY CKKAKPIPRR
   301  CSAKEWSCQL PCGQKLLCGQ HKCENPCHAG SCQPCPRVSR QKCVCGKKVA ERSCASPLWH
   361  CDQVCGKTLP CGNHTCEQVC HVGACGECPR SGKRFCPCQK SKFSLPCTED VPTCGDSCDK
   421  VLECGIHRCS QRCHRGPCET CRQEVEKHCR CGKHTKRMPC HKPYLCETKC VKMRDCQKHQ
   481  CRRKCCPGNC PPCDQNCGRT LGCRNHKCPS VCHRGSCYPC PETVDVKCNC GNTKVTVPCG
   541  RERTTRPPKC KEQCSRPPTC HHTSQEKHRC HFGSCPPCHQ PCQKVLEKCG HLCPAPCHDQ
   601  ALIKQTGRHQ PTGPWEQPSE PAFIQTALPC PPCQVPIPME CLGKHEVSPL PCHAVGPYSC
   661  KRVCGRILDC QNHTCMKECH KVTKTDGCTG KNKAGPECLH CEEGCSKSRP LGCLHPCILR
   721  CHPGECPPCV QMLRIKCHCK ITSLYVECRK ITTADVNEKN LLSCCKNQCP KELPCGHRCK
   781  EMCHPGECPF NCNQKVKLRC PCKRIKKELQ CNKVRENQVS IECDTTCKEM KRKASEIKEA
   841  EAKAALEEEK RRQQAELEAF ENRLKGRRKK NRKRDEVAVE LSLWQKHKYY LISVCGVVVV
   901  VFAWYITHDV N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFXL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

13 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NFXL1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 158 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Structural heart defects and renal anomalies syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.51

gnomAD pLI

0

gnomAD missense Z

1.39

DepMap mean gene effect

0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of DNA-templated transcription

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• chromatin
• membrane
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, NF-X1-type
• Zinc finger, RING-type
• Transcription factor NFX1 family
• NF-X1 type zinc finger

KeywordsUniProt

• Coiled coil
• Membrane
• Metal-binding
• Phosphoprotein
• Repeat
• Transmembrane
• Transmembrane helix
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of NFXL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CANX