NFE4
Transcription factor NF-E4
Also known as: NFE4_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for NFE4 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
179 residues, UniProt reviewed canonical sequence.
>Q86UQ8|NFE4
1 MPRVVCWHTL KSLNGYKNLS SGAETREGLR SSSPVDLPLR PRKQATAAGQ RKLLSLQLLL
61 CACTSVTDLT YWGPAGHGAT APHRSLLAIH LHLVPASSAA MKATGPHNAQ TQVNPQGHAP
121 SAEDPTGTWT VSGPCKDHPH PFLSQSNPPT RISSALPLKT DSALEQTPQQ LPSLHLSQGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NFE4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.7
OntologyGO
Biological processes
- positive regulation of transcription by RNA polymerase II
- protein-containing complex assembly
- regulation of DNA-templated transcription
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor binding
- protein homodimerization activity
- transcription coregulator activity
Cellular components
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NFE4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NFE4 as an antibody target. Whether an autoantibody or antibody against NFE4 could matter depends on whether native NFE4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NFE4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NFE4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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