Seroatlas · Human Serome Atlas

NCOA7

Nuclear receptor coactivator 7

Also known as: dJ187J11.3, ERAP140, NCOA7_HUMAN, TLDC4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NI08
Gene: NCOA7
Ensembl: ENSG00000111912
Chromosome: 6
Canonical length: 942 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Nuclear bodies,Golgi apparatus

OverviewNCBI Gene

Enables nuclear receptor binding activity and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

942 residues, UniProt reviewed canonical sequence.

>Q8NI08|NCOA7
     1  MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL EPDKCNIAVE
    61  EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK KEKKMVVQKP HGTMEYTAGN
   121  QDTLNSIALK FNITPNKLVE LNKLFTHTIV PGQVLFVPDA NSPSSTLRLS SSSPGATVSP
   181  SSSDAEYDKL PDADLARKAL KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM
   241  IVTPNNIMFD PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD
   301  LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP LEKSTGHTPT
   361  KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA FESTAKENFL GEDDDFVDLE
   421  ELSSQTGGGM HKKDTLKECL SLDPEERKKA ESQINNSAVE MQVQSALAFL GTENDVELKG
   481  ALDLETCEKQ DIMPEVDKQS GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL
   541  QKTELSDGKS IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN
   601  VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE KSKTPPMFLC
   661  IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV DHLYTFFVQW SPDVYGKDAK
   721  EQGFVVVEKE ELNMIDNFFS EPTTKSWEII TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS
   781  ALLENMHIEQ LARRLPARVQ GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN
   841  QIFGAYATHP FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR
   901  FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCOA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 95 nTPM
adrenal gland: 57 nTPM
kidney: 53 nTPM
adipose tissue: 51 nTPM
lung: 49 nTPM
cerebral cortex: 49 nTPM

Single-cell type

epididymal basal cells: 1,215 nCPM
salivary ionocytes: 925 nCPM
urothelial cells: 806 nCPM
salivary acinar cells: 790 nCPM
respiratory basal cells: 705 nCPM
alveolar cells type 2: 697 nCPM

Immune cell

plasmacytoid DC: 34 nTPM
MAIT T-cell: 24 nTPM
gdT-cell: 19 nTPM
memory CD4 T-cell: 18 nTPM
memory B-cell: 18 nTPM
basophil: 17 nTPM

Brain region

medulla oblongata: 208 nTPM
cerebral cortex: 208 nTPM
pons: 200 nTPM
white matter: 199 nTPM
hypothalamus: 154 nTPM
basal ganglia: 154 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0
gnomAD missense Z: 0.56
DepMap mean gene effect: 0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCOA7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ESR1
ESR2A
ESR2B
PPARG
RARA
THRB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCOA7 as an antibody target. Whether an autoantibody or antibody against NCOA7 could matter depends on whether native NCOA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCOA7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCOA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...