Seroatlas · Human Serome Atlas

NCF1C

Putative neutrophil cytosol factor 1C

Also known as: NCF1C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MVU1
Gene
NCF1C
Canonical length
366 aa

OverviewNCBI Gene

No narrative summary is available for NCF1C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>A8MVU1|NCF1C
     1  MYMFLVKWQD LSEKVVYRRF TEIYEFHKTL KEMFPIEAGA INPENRIIPH LPAPKWFDGQ
    61  RAAENHQGTL TEYCSTLMSL PTKISRCPHL LDFFKVRPDD LKLPTDNQTK KPETYLMPKD
   121  GKSTATDITG PIILQTYRAI ADYEKTSGSE MALSTGDVVE VVEKSESGWW FCQMKAKRGW
   181  IPASFLEPLD SPDETEDPEP NYAGEPYVAI KAYTAVEGDE VSLLEGEAVE VIHKLLDGWW
   241  VIRKDDVTGY FPSMYLQKSG QDVSQAQRQI KRGAPPRRSS IRNAHSIHQR SRKRLSQDAY
   301  RRNSVRFLQQ RRRQARPGPQ SPGSPLEEER QTQRSKPQPA VPPRPSADLI LNRCSESTKR
   361  KLASAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCF1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCF1C as an antibody target. Whether an autoantibody or antibody against NCF1C could matter depends on whether native NCF1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCF1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCF1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NCF1C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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