Seroatlas · Human Serome Atlas

NCF1B

Putative neutrophil cytosol factor 1B

Also known as: NCF1B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NI72
Gene
NCF1B
Canonical length
391 aa

OverviewNCBI Gene

No narrative summary is available for NCF1B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>A6NI72|NCF1B
     1  MGDTFIRHIA LLGFEKRFVP SQHYVRYMFL VKWQDLSEKV VYRRFTEIYE FHKTLKEMFP
    61  IEAGAINPEN RIIPHLPAPK WFDGQRAAEN HQGTLTEYCG TLMSLPTKIS RCPHLLDFFK
   121  VRPDDLKLPT DNQTKKPETY LMPKDGKSTA TDITGPIILQ TYRAIANYEK TSGSEMALST
   181  GDVVEVVEKS ESGWWFCQMK AKRGWIPASF LEPLDSPDET EDPEPNYAGE PYVAIKAYTA
   241  VEGDEVSLLE GEAVEVIHKL LDGWWVIRKD DVTGYFPSMY LQKSGQDVSQ AQRQIKRGAP
   301  PRRSSIRNVH SIHQRSRKRL SQDAYRRNSV RFLQQRRRQA RPGPQSPGSP LEEERQTQRS
   361  KPQPAVPPRP SADLILNRCS ESTKRKLASA V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCF1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCF1B as an antibody target. Whether an autoantibody or antibody against NCF1B could matter depends on whether native NCF1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCF1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCF1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NCF1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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