Seroatlas · Human Serome Atlas

NCAPH2

Condensin-2 complex subunit H2

Also known as: 384D8-2, CAP-H2, CNDH2_HUMAN, hCAP-H2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IBW4
Gene: NCAPH2
Ensembl: ENSG00000025770
Chromosome: 22
Canonical length: 605 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cell Junctions,Cytokinetic bridge

OverviewNCBI Gene

This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

605 residues, UniProt reviewed canonical sequence.

>Q6IBW4|NCAPH2
     1  MEDVEARFAH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDEGKTT MNFIEAALLI
    61  QGSACVYSKK VEYLYSLVYQ ALDFISGKRR AKQLSSVQED RANGVASSGV PQEAENEFLS
   121  LDDFPDSRTN VDLKNDQTPS EVLIIPLLPM ALVAPDEMEK NNNPLYSRQG EVLASRKDFR
   181  MNTCVPHPRG AFMLEPEGMS PMEPAGVSPM PGTQKDTGRT EEQPMEVSVC RSPVPALGFS
   241  QEPGPSPEGP MPLGGGEDED AEEAVELPEA SAPKAALEPK ESRSPQQSAA LPRRYMLRER
   301  EGAPEPASCV KETPDPWQSL DPFDSLESKP FKKGRPYSVP PCVEEALGQK RKRKGAAKLQ
   361  DFHQWYLAAY ADHADSRRLR RKGPSFADME VLYWTHVKEQ LETLRKLQRR EVAEQWLRPA
   421  EEDHLEDSLE DLGAADDFLE PEEYMEPEGA DPREAADLDA VPMSLSYEEL VRRNVELFIA
   481  TSQKFVQETE LSQRIRDWED TVQPLLQEQE QHVPFDIHTY GDQLVSRFPQ LNEWCPFAEL
   541  VAGQPAFEVC RSMLASLQLA NDYTVEITQQ PGLEMAVDTM SLRLLTHQRA HKRFQTYAAP
   601  SMAQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCAPH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 74 nTPM
cerebellum: 50 nTPM
testis: 50 nTPM
pituitary gland: 38 nTPM
ovary: 37 nTPM
pancreas: 35 nTPM

Single-cell type

late spermatids: 189 nCPM
extravillous trophoblasts: 67 nCPM
migrating cytotrophoblasts: 51 nCPM
differentiating spermatogonia: 49 nCPM
esophageal basal cells: 46 nCPM
cytotrophoblasts: 42 nCPM

Immune cell

MAIT T-cell: 23 nTPM
naive CD4 T-cell: 20 nTPM
memory CD4 T-cell: 20 nTPM
T-reg: 19 nTPM
memory CD8 T-cell: 19 nTPM
gdT-cell: 19 nTPM

Brain region

cerebral cortex: 43 nTPM
basal ganglia: 42 nTPM
medulla oblongata: 42 nTPM
white matter: 42 nTPM
cerebellum: 41 nTPM
hypothalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.7
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chromatin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Condensin II complex subunit H2, N-terminal
Condensin II complex subunit H2, middle domain
Condensin-2 complex subunit H2, C-terminal
Condensin-2 complex subunit H2
Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
Condensin II complex subunit CAP-H2 or CNDH2, C-terminal wHTH domain
Condensin II complex subunit CAP-H2 or CNDH2, mid domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCAPH2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCAPH2 as an antibody target. Whether an autoantibody or antibody against NCAPH2 could matter depends on whether native NCAPH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCAPH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCAPH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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