Seroatlas · Human Serome Atlas

NCAPG2

Condensin-2 complex subunit G2

Also known as: CAP-G2, CNDG2_HUMAN, FLJ20311, hCAP-G2, LUZP5, MTB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XI2
Gene: NCAPG2
Ensembl: ENSG00000146918
Chromosome: 7
Canonical length: 1143 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

1143 residues, UniProt reviewed canonical sequence.

>Q86XI2|NCAPG2
     1  MEKRETFVQA VSKELVGEFL QFVQLDKEAS DPFSLNELLD ELSRKQKEEL WQRLKNLLTD
    61  VLLESPVDGW QVVEAQGEDN METEHGSKMR KSIEIIYAIT SVILASVSVI NESENYEALL
   121  ECVIILNGIL YALPESERKL QSSIQDLCVT WWEKGLPAKE DTGKTAFVML LRRSLETKTG
   181  ADVCRLWRIH QALYCFDYDL EESGEIKDML LECFININYI KKEEGRRFLS CLFNWNINFI
   241  KMIHGTIKNQ LQGLQKSLMV YIAEIYFRAW KKASGKILEA IENDCIQDFM FHGIHLPRRS
   301  PVHSKVREVL SYFHHQKKVR QGVEEMLYRL YKPILWRGLK ARNSEVRSNA ALLFVEAFPI
   361  RDPNLHAIEM DSEIQKQFEE LYSLLEDPYP MVRSTGILGV CKITSKYWEM MPPTILIDLL
   421  KKVTGELAFD TSSADVRCSV FKCLPMILDN KLSHPLLEQL LPALRYSLHD NSEKVRVAFV
   481  DMLLKIKAVR AAKFWKICPM EHILVRLETD SRPVSRRLVS LIFNSFLPVN QPEEVWCERC
   541  VTLVQMNHAA ARRFYQYAHE HTACTNIAKL IHVIRHCLNA CIQRAVREPP EDEEEEDGRE
   601  KENVTVLDKT LSVNDVACMA GLLEIIVILW KSIDRSMENN KEAKLYTINK FASVLPEYLK
   661  VFKDDRCKIP LFMLMSFMPA SAVPPFSCGV ISTLRSREEG AVDKSYCTLL DCLCSWGQVG
   721  HILELVDNWL PTEHAQAKSN TASKGRVQIH DTRPVKPELA LVYIEYLLTH PKNRECLLSA
   781  PRKKLNHLLK ALETSKADLE SLLQTPGGKP RGFSEAAAPR AFGLHCRLSI HLQHKFCSEG
   841  KVYLSMLEDT GFWLESKILS FIQDQEEDYL KLHRVIYQQI IQTYLTVCKD VVMVGLGDHQ
   901  FQMQLLQRSL GIMQTVKGFF YVSLLLDILK EITGSSLIQK TDSDEEVAML LDTVQKVFQK
   961  MLECIARSFR KQPEEGLRLL YSVQRPLHEF ITAVQSRHTD TPVHRGVLST LIAGPVVEIS
  1021  HQLRKVSDVE ELTPPEHLSD LPPFSRCLIG IIIKSSNVVR SFLDELKACV ASNDIEGIVC
  1081  LTAAVHIILV INAGKHKSSK VREVAATVHR KLKTFMEITL EEDSIERFLY ESSSRTLGEL
  1141  LNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCAPG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

thymus: 26 nTPM
bone marrow: 23 nTPM
testis: 14 nTPM
tonsil: 13 nTPM
lymph node: 12 nTPM
appendix: 8.3 nTPM

Single-cell type

monocyte progenitors: 197 nCPM
erythrocyte progenitors: 157 nCPM
neutrophil progenitors: 128 nCPM
megakaryocyte progenitors: 99 nCPM
early primary spermatocytes: 71 nCPM
endometrial luminal cells: 66 nCPM

Immune cell

MAIT T-cell: 7.5 nTPM
T-reg: 7.2 nTPM
basophil: 5.9 nTPM
gdT-cell: 5.2 nTPM
memory CD4 T-cell: 5.2 nTPM
NK-cell: 5.2 nTPM

Brain region

cerebellum: 6 nTPM
white matter: 5.4 nTPM
basal ganglia: 5.3 nTPM
hippocampal formation: 5.3 nTPM
cerebral cortex: 5.1 nTPM
hypothalamus: 5.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NCAPG2.

Disease | AllUniProt

Conditions NCAPG2 is implicated in, by any mechanism.

Khan-Khan-Katsanis syndrome (3KS) MIM:618460

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 203 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Khan-Khan-Katsanis syndrome

Disease | ImmuneIEDB

Conditions an epitope on NCAPG2 was assayed in.

skin melanoma T cell
melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 1.94
DepMap mean gene effect: -0.96
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
Condensin-2 complex subunit G2
Condensin II non structural maintenance of chromosomes subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCAPG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NCAPH2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCAPG2 as an antibody target. Whether an autoantibody or antibody against NCAPG2 could matter depends on whether native NCAPG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCAPG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCAPG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...