Seroatlas · Human Serome Atlas

NBPF8

NBPF family member NBPF8

Also known as: NBPF8_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3BBV2
Gene: NBPF8
Canonical length: 942 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for NBPF8 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

942 residues, UniProt reviewed canonical sequence.

>Q3BBV2|NBPF8
     1  MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFVNLKE RCFLTQLAGF LANRQKKYKY
    61  EECKDLIRFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLK EKLQEGRDAS
   121  RSLNEHLQAL LTLDEPDKSQ GQDLQEQLAE GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE
   181  KVQKSSAPRE VQKAEESKVP EDSLEECAIT CSNSHGPCDS NQPHKNIKIT FEEDEVNSTL
   241  VVDRESSHDE CQDALNILSV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLHPQLA
   301  EKKQQFRNLK EKCFLTQLAG FLANRQNKYK YEECKDLIKS MLRNERQFKE EKLAEQLKQA
   361  EELRQYKVLV HTQERELTQL REKLREGRDA SLSLNEHLQA LLTPDEPDKS QGQDLQEQLA
   421  EGCRLAQHLV QKLSPENDND DDEDVQVEVA EKVQKSSAPR EMQKAEEKEV PEDSLEECAI
   481  TYSNSHGPYD SNQPHRKTKI TFEEDKVDSA LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK
   541  GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPEMLASYKS YSSTFHSLEE QQVCMAVDIG
   601  RHRWDQVKKE DQEATGPRLS RELLDEKGPE VLQDSLDRCY STPSGCLELT DSCQPYRSAF
   661  YILEQQRVGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLD EKEPEVLQDS LDRCYSTPSG
   721  YLELPDLGQP YSSAVYSLEE QYLGLALDVD RIKKDQEEEE DQGPPCPRLS RELLEVVEPE
   781  VLQDSLDRCY STPSSCLEQP DSCQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKIRRGRR
   841  SKKKRRRGRK EGEEDQNPPC PRLNSVLMEV EEPEVLQDSL DRCYSTPSMY CELRDSFQHY
   901  RSVFYSFEEQ HISFALDMDN RFFTLTVTSL YLVFQMGVIF PQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NBPF8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 5.7 nTPM

Expression across tissuesHPA

Tissue

liver: 5.7 nTPM
epididymis: 4.8 nTPM
retina: 3.1 nTPM
appendix: 2.4 nTPM
lymph node: 2.3 nTPM
ovary: 2.3 nTPM

Single-cell type

epicardial cells: 55 nCPM
cardiomyocytes: 52 nCPM
fibro-adipogenic progenitors: 45 nCPM
hematopoietic stem cells: 25 nCPM
megakaryocyte-erythroid progenitors: 24 nCPM
pituitary stem cells: 22 nCPM

Immune cell

memory CD4 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
classical monocyte: 0.3 nTPM
gdT-cell: 0.3 nTPM
MAIT T-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM

Brain region

cerebellum: 16 nTPM
choroid plexus: 7.9 nTPM
amygdala: 6.8 nTPM
hypothalamus: 6.8 nTPM
cerebral cortex: 6.7 nTPM
hippocampal formation: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.97
gnomAD pLI: 0
gnomAD missense Z: -2.88

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NBPF8 as an antibody target. Whether an autoantibody or antibody against NBPF8 could matter depends on whether native NBPF8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NBPF8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NBPF8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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