Seroatlas · Human Serome Atlas

NBPF20

NBPF family member NBPF20

Also known as: NBPFK_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DPF2
Gene
NBPF20
Canonical length
5207 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for NBPF20 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

5207 residues, UniProt reviewed canonical sequence.

>P0DPF2|NBPF20
     1  MFRLSRELLD EKGPEVLQDS LDRCYSTPSG CLELTDSCQP YRSAFYVLEQ QRIGLAVDMD
    61  EIEKYQEVEE DQDPSCPRLS RELLDEKEPE VLQDSLDRCY STPSGYLELP DLGQPYSSAV
   121  YSLEEQYLGL ALDVDRTKKD QEEEEDQGPP CPRLSRELLE VVEPEVLQDS LDRCYSTPSS
   181  CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKK RRGRRSKKER RRGRKEGEED
   241  QNPPCPRLSR ELLDEKGPEV LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA
   301  VDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL DRCYSTPSGY LELPDLGQPY
   361  SSAVYSLEEQ YLGLALDVDR TKKDQEEEED QGPPCPRLSR ELLEVVEPEV LQDSLDRCYS
   421  TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKERRRGRKE
   481  GEEDQNPPCP RLSRELLDEK GPEVLQDSLD RSYSTPSGCL ELTDSCQPYR SAFYVLEQQR
   541  VGLAVDMDEI EKYQEVEEDQ DPSCPRLSRE LLDEKEPEVL QDSLDRCYST PSGYLELPDL
   601  GQPYSSAVYS LEEQYLGLAL DVDRTKKDQE EEEDQGPPCP RLSRELLEVV EPEVLQDSLD
   661  RCYSTPSSCL EQPDSCQPYG SSFYALEEKH VGFSLDVGEI EKKGKGKKRR GRRSKKERRR
   721  GRKEGEEDQN PPCPRLSREL LDEKGPEVLQ DSLDRCYSTP SGCLELTDSC QPYRSAFYVL
   781  EQQRVGLAVD MDEIEKYQEV EEDQDPSCPR LSRELLDEKE PEVLQDSLDR CYSTPSGYLE
   841  LPDLGQPYSS AVYSLEEQYL GLALDVDRTK KDQEEEEDQG PPCPRLSREL LEVVEPEVLQ
   901  DSLDRCYSTP SSCLEQPDSC QPYGSSFYAL EEKHVGFSLD VGEIEKKGKG KKRRGRRSKK
   961  ERRRGRKEGE EDQNPPCPRL SRELLDEKGP EVLQDSLDRS YSTPSGCLEL TDSCQPYRSA
  1021  FYVLEQQRVG LAVDMDEIEK YQEVEEDQDP SCPRLSRELL DEKEPEVLQD SLDRCYSTPS
  1081  GYLELPDLGQ PYSSAVYSLE EQYLGLALDV DRTKKDQEEE EDQGPPCPRL SRELLEVVEP
  1141  EVLQDSLDRC YSTPSSCLEQ PDSCQPYGSS FYALEEKHVG FSLDVGEIEK KGKGKKRRGR
  1201  RSKKERRRGR KEGEEDQNPP CPRLSRELLD EKGPEVLQDS LDRSYSTPSG CLELTDSCQP
  1261  YRSAFYVLEQ QRVGLAVDMD EIEKYQEVEE DQDPSCPRLS RELLDEKEPE VLQDSLDRCY
  1321  STPSGYLELP DLGQPYSSAV YSLEEQYLGL ALDVDRTKKD QEEEEDQGPP CPRLSRELLE
  1381  VVEPEVLQDS LDRCYSTPSS CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKK
  1441  RRGRRSKKER RRGRKEGEED QTPPCPRLSR ELLDEKGPEV LQDSLDRSYS TPSGCLELTD
  1501  SCQPYRSAFY VLEQQRVGLA VDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL
  1561  DRCYSTPSGY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR TKKDQEEEED QGPPCPRLSR
  1621  ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG
  1681  KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLSRELLDEK GPEVLQDSLD RSYSTPSGCL
  1741  ELTDSCQPYR SAFYVLEQQR VGLAVDMDEI EKYQEVEEDQ DPSCPRLSRE LLDEKEPEVL
  1801  QDSLDRCYST PSGYLELPDL GQPYSSAVYS LEEQYLGLAL DVDRTKKDQE EEEDQGPPCP
  1861  RLSRELLEVV EPEVLQDSLD RCYSTPSSCL EQPDSCQPYG SSFYALEEKH VGFSLDVGEI
  1921  EKKGKGKKRR GRRSKKERRR GRKEGEEDQN PPCPRLSREL LDEKGPEVLQ DSLDRCYSTP
  1981  SGCLELTDSC QPYRSAFYVL EQQRVGLAVD MDEIEKYQEV EEDQDPSCPR LSRELLDEKE
  2041  PEVLQDSLDR CYSTPSGYLE LPDLGQPYSS AVYSLEEQYL GLALDVDRTK KDQEEEEDQG
  2101  PPCPRLSREL LEVVEPEVLQ DSLDRCYSTP SSCLEQPDSC QPYGSSFYAL EEKHVGFSLD
  2161  VGEIEKKGKG KKRRGRRSKK ERRRGRKEGE EDQNPPCPRL SRELLDEKGP EVLQDSLDRC
  2221  YSTPSGCLEL TDSCQPYRSA FYVLEQQRVG LAVDMDEIEK YQEVEEDQDP SCPRLSRELL
  2281  DEKEPEVLQD SLDRCYSTPS GYLELPDLGQ PYSSAVYSLE EQYLGLALDV DRTKKDQEEE
  2341  EDQGPPCPRL SRELLEVVEP EVLQDSLDRC YSTPSSCLEQ PDSCQPYGSS FYALEEKHVG
  2401  FSLDVGEIEK KGKGKKRRGR RSKKERRRGR KEGEEDQNPP CPRLSRELLD EKGPEVLQDS
  2461  LDRCYSTPSG CLELTDSCQP YRSAFYVLEQ QRVGLAVDMD EIEKYQEVEE DQDPSCPRLS
  2521  RELLDEKEPE VLQDSLDRCY STPSGYLELP DLGQPYSSAV YSLEEQYLGL ALDVDRTKKD
  2581  QEEEEDQGPP CPRLSRELLE VVEPEVLQDS LDRCYSTPSS CLEQPDSCQP YGSSFYALEE
  2641  KHVGFSLDVG EIEKKGKGKK RRGRRSKKER RRGRKEGEED QNPPCPRLSR ELLDEKGPEV
  2701  LQDSLDRSYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA VDMDEIEKYQ EVEEDQDPSC
  2761  PRLSRELLDE KEPEVLQDSL DRCYSTPSGY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR
  2821  TKKDQEEEED QGPPCPRLSR ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY
  2881  ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLSRELLDEK
  2941  GPEVLQDSLD RSYSTPSGCL ELTDSCQPYR SAFYVLEQQR VGLAVDMDEI EKYQEVEEDQ
  3001  DPSCPRLSRE LLDEKEPEVL QDSLDRCYST PSGYLELPDL GQPYSSAVYS LEEQYLGLAL
  3061  DVDRTKKDQE EEEDQGPPCP RLSRELLEVV EPEVLQDSLD RCYSTPSSCL EQPDSCQPYG
  3121  SSFYALEEKH VGFSLDVGEI EKKGKGKKRR GRRSKKERRR GRKEGEEDQN PPCPRLSREL
  3181  LDEKGPEVLQ DSLDRSYSTP SGCLELTDSC QPYRSAFYVL EQQRVGLAVD MDEIEKYQEV
  3241  EEDQDPSCPR LSRELLDEKE PEVLQDSLDR CYSTPSGYLE LPDLGQPYSS AVYSLEEQYL
  3301  GLALDVDRTK KDQEEEEDQG PPCPRLSREL LEVVEPEVLQ DSLDRCYSTP SSCLEQPDSC
  3361  QPYGSSFYAL EEKHVGFSLD VGEIEKKGKG KKRRGRRSKK ERRRGRKEGE EDQNPPCPRL
  3421  SRELLDEKGP EVLQDSLDRS YSTPSGCLEL TDSCQPYRSA FYVLEQQRVG LAVDMDEIEK
  3481  YQEVEEDQDP SCPRLSRELL DEKEPEVLQD SLDRCYSTPS GYLELPDLGQ PYSSAVYSLE
  3541  EQYLGLALDV DRTKKDQEEE EDQGPPCPRL SRELLEVVEP EVLQDSLDRC YSTPSSCLEQ
  3601  PDSCQPYGSS FYALEEKHVG FSLDVGEIEK KGKGKKRRGR RSKKERRRGR KEGEEDQNPP
  3661  CPRLSRELLD EKGPEVLQDS LDRCYSTPSG CLELTDSCQP YRSAFYVLEQ QRVGLAVDMD
  3721  EIEKYQEVEE DQDPSCPRLS RELLDEKEPE VLQDSLDRCY STPSGYLELP DLGQPYSSAV
  3781  YSLEEQYLGL ALDVDRTKKD QEEEEDQGPP CPRLSRELLE VVEPEVLQDS LDRCYSTPSS
  3841  CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKK RRGRRSKKER RRGRKEGEED
  3901  QNPPCPRLSR ELLDEKGPEV LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA
  3961  VDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL DRCYSTPSGY LELPDLGQPY
  4021  SSAVYSLEEQ YLGLALDVDR TKKDQEEEED QGPPCPRLSR ELLEVVEPEV LQDSLDRCYS
  4081  TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKERRRGRKE
  4141  GEEDQTPPCP RLSRELLDEK GPEVLQDSLD RCYSTPSGCL ELTDSCQPYR SAFYVLEQQR
  4201  VGLAVDMDEI EKYQEVEEDQ DPSCPRLSRE LLDEKEPEVL QDSLDRCYST PSGYLELPDL
  4261  GQPYSSAVYS LEEQYLGLAL DVDRTKKDQE EEEDQGPPCP RLSRELLEVV EPEVLQDSLD
  4321  RCYSTPSSCL EQPDSCQPYG SSFYALEEKH VGFSLDVGEI EKKGKGKKRR GRRSKKERRR
  4381  GRKEGEEDQN PPCPRLSREL LDEKEPEVLQ DSLDRCYSTP SGYLELPDLG QPYSSAVYSL
  4441  EEQYLGLALD VDRTKKDQEE EEDQGPPCPR LSRELLEVVE PEVLQDSLDR CYSTPSSCLE
  4501  QPDSCQPYGS SFYALEEKHV GFSLDVGEIE KKGKGKKRRG RRSKKERRRG RKEGEEDQNP
  4561  PCPRLSRELL DEKEPEVLQD SLDRCYSTPS GYLELPDLGQ PYSSAVYSLE EQYLGLALDV
  4621  DRTKKDQEEE EDQGPPCPRL SRELLEVVEP EVLQDSLDRC YSTPSSCLEL TDSCQPYRSA
  4681  FYVLEQQRVG LAVDMDEIEK YQEVEEDQDP SCPRLSRELL DEKEPEVLQD SLDRCYSTPS
  4741  GYLELPDLGQ PYSSAVYSLE EQYLGLALDV DRTKKDQEEE EDQGPPCPRL SRELLEVVEP
  4801  EVLQDSLDRC YSTPSSCLEQ PDSCQPYGSS FYALEEKHVG FSLDVGEIEK KGKGKKRRGR
  4861  RSKKERRRGR KEGEEDQNPP CPRLSRELLD EKGPEVLQDS LDRCYSTPSG CLELTDSCQP
  4921  YRSAFYVLEQ QRVGLAVDMD EIEKYQEVEE DQDPSCPRLS RELLDEKEPE VLQDSLDRCY
  4981  STPSGYLELP DLGQPYSSAV YSLEEQYLGL ALDVDRTKKD QEEEEDQGPP CPRLSRELLE
  5041  VVEPEVLQDS LDRCYSTPSS CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKK
  5101  RRGRRSKKKR RRGRKEGEED QNPPCPRLNG VLMEVEEPEV LQDSLDGCYS TPSMYFELPD
  5161  SFQHYRSVFY SFEEQHISFA LYVDNRFFTL TVTSLHLVFQ MGVIFPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NBPF20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0
Highest tissue expression
2.6 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 2.6 nTPM
  • liver: 1.3 nTPM
  • retina: 1.1 nTPM
  • parathyroid gland: 0.9 nTPM
  • testis: 0.9 nTPM
  • epididymis: 0.8 nTPM

Single-cell type

  • hepatocytes: 40 nCPM
  • late primary spermatocytes: 26 nCPM
  • adrenal cortex cells: 25 nCPM
  • somatotrophs: 21 nCPM
  • early primary spermatocytes: 20 nCPM
  • corticotrophs: 17 nCPM

Immune cell

  • plasmacytoid DC: 0.7 nTPM
  • naive B-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM

Brain region

  • cerebellum: 13 nTPM
  • midbrain: 10 nTPM
  • pons: 5.6 nTPM
  • thalamus: 5.6 nTPM
  • basal ganglia: 5.1 nTPM
  • cerebral cortex: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.97
gnomAD pLI
0
gnomAD missense Z
-7.67

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NBPF20 as an antibody target. Whether an autoantibody or antibody against NBPF20 could matter depends on whether native NBPF20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NBPF20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NBPF20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NBPF20. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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