Seroatlas · Human Serome Atlas

NBPF19

NBPF family member NBPF19

Also known as: NBPFJ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A087WUL8
Gene
NBPF19
Ensembl
ENSG00000271383
Chromosome
1
Canonical length
3843 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Microtubules,Cytokinetic bridge,Primary cilium,Cytosol,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

3843 residues, UniProt reviewed canonical sequence.

>A0A087WUL8|NBPF19
     1  MVVSAGPWSS EKAEMNILEI NETLRPQLAE KKQQFRNLKE KCFLTQLAGF LANRQKKYKY
    61  EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLFH SQERELTQLR EKLREGRDAS
   121  RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLAQHLVQ KLSPENDNDD DEDVQVEVAE
   181  KVQKSSAPRE MQKAEEKEVP EDSLEECAIT YSNSHGPYDS NQPHRKTKIT FEEDKVDSTL
   241  IGSSSHVEWE DAVHIIPENE SDDEEEEEKG PVSPRNLQES EEEEVPQESW DEGYSTLSIP
   301  PEMLASYQSY SSTFHSLEEQ QVCMAVDIGR HRWDQVKKED QEATGPRLSR ELLDEKGPEV
   361  LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA IDMDEIEKYQ EVEEDQDPSC
   421  PRLSRELLDE KEPEVLQDSL DRCYSIPSGY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR
   481  IKKDQEEEED QDPPCPRLSR ELVEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY
   541  ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLSRELLDEK
   601  GPEVLQDSLD RCYSTPSGCL ELTDSCQPYR SAFYILEQQC VGLAVDMDEI EKYQEVEEDQ
   661  DPSCPRLSRE LLDEKEPEVL QDSLDRCYSI PSGYLELPDL GQPYSSAVYS LEEQYLGLAL
   721  DVDRIKKDQE EEEDQDPPCP RLSRELVEVV EPEVLQDSLD RCYSTPSSCL EQPDSCQPYG
   781  SSFYALEEKH VGFSLDVGEI EKKGKGKKRR GRRSKKERRR GRKEGEEDQN PPCPRLSREL
   841  LDEKGPEVLQ DSLDRCYSTP SGCLELTDSC QPYRSAFYIL EQQCVGLAID MDEIEKYQEV
   901  EEDQDPSCPR LSRELLDEKE PEVLQDSLDR CYSIPSGYLE LPDLGQPYSS AVYSLEEQYL
   961  GLALDVDRIK KDQEEEEDQD PPCPRLSREL VEVVEPEVLQ DSLDRCYSTP SSCLEQPDSC
  1021  QPYGSSFYAL EEKHVGFSLD VGEIEKKGKG KKRRGRRSKK ERRRGRKEGE EDQNPPCPRL
  1081  SRELLDEKGP EVLQDSLDRC YSTPSGCLEL TDSCQPYRSA FYILEQQCVG LAVDMDEIEK
  1141  YQEVEEDQDP SCPRLSRELL DEKEPEVLQD SLDRCYSIPS GYLELPDLGQ PYSSAVYSLE
  1201  EQYLGLALDV DRIKKDQEEE EDQDPPCPRL SRELVEVVEP EVLQDSLDRC YSTPSSCLEQ
  1261  PDSCQPYGSS FYALEEKHVG FSLDVGEIEK KGKGKKRRGR RSKKERRRGR KEGEEDQNPP
  1321  CPRLSRELLD EKGPEVLQDS LDRCYSTPSG CLELTDSCQP YRSAFYILEQ QCVGLAVDMD
  1381  EIEKYQEVEE DQDPSCPRLS RELLDEKEPE VLQDSLDRCY SIPSGYLELP DLGQPYSSAV
  1441  YSLEEQYLGL ALDVDRIKKD QEEEEDQDPP CPRLSRELVE VVEPEVLQDS LDRCYSTPSS
  1501  CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKK RRGRRSKKER RRGRKEGEED
  1561  QNPPCPRLSR ELLDEKGPEV LQDSLDRCYS TPSGCLELTD SCQPYRSAFY ILEQQCVGLA
  1621  VDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL DRCYSIPSGY LELPDLGQPY
  1681  SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QDPPCPRLSR ELLEVVEPEV LQDSLDRCYS
  1741  TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKERRRGRKE
  1801  GEEDQNPPCP RLSRELLDEK GPEVLQDSLD RCYSTPSGCL ELTDSCQPYR SAFYILEQQC
  1861  VGLAVDMDEI EKYQEVEEDQ DPSCPRLSRE LLDEKEPEVL QDSLDRCYST PSGYLELPDL
  1921  GQPYSSAVYS LEEQYLGLAL DVDRIKKDQE EEEDQGPPCP RLSRELLEVV EPEVLQDSLD
  1981  RCYSTPSSCL EQPDSCQPYG SSFYALEEKH VGFSLDVGEI EKKGKGKKRR GRRSKKERRR
  2041  GRKEGEEDQN PPCPRLSREL LDEKGPEVLQ DSLDRCYSTP SGCLELTDSC QPYRSAFYIL
  2101  EQQCVGLAVD MDEIEKYQEV EEDQDPSCPR LSRELLDEKE PEVLQDSLDR CYSTPSGYLE
  2161  LPDLGQPYSS AVYSLEEQYL GLALDVDRIK KDQEEEEDQG PPCPRLSREL LEVVEPEVLQ
  2221  DSLDRCYSTP SSCLEQPDSC QPYGSSFYAL EEKHVGFSLD VGEIEKKGKG KKRRGRRSKK
  2281  ERRRGRKEGE EDQNPPCPRL SRELLDEKGP EVLQDSLDRC YSTPSGCLEL TDSCQPYRSA
  2341  FYILEQQCVG LAVDMDEIEK YQEVEEDQDP SCPRLSRELL DEKEPEVLQD SLDRCYSTPS
  2401  GYLELPDLGQ PYSSAVYSLE EQYLGLALDV DRIKKDQEEE EDQGPPCPRL SRELLEVVEP
  2461  EVLQDSLDRC YSTPSSCLEQ PDSCQPYGSS FYALEEKHVG FSLDVGEIEK KGKGKKRRGR
  2521  RSKKERRRGR KEGEEDQNPP CPRLSRELLD EKGPEVLQDS LDRCYSTPSG CLELTDSCQP
  2581  YRSAFYILEQ QCVGLAVDMD EIEKYQEVEE DQDPSCPRLS RELLDEKEPE VLQDSLDRCY
  2641  STPSGYLELP DLGQPYSSAV YSLEEQYLGL ALDVDRIKKD QEEEEDQGPP CPRLSRELLE
  2701  VVEPEVLQDS LDRCYSTPSS CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKK
  2761  RRGRRSKKER RRGRKEGEED QNPPCPRLSR ELLDEKGPEV LQDSLDRCYS TPSGCLELTD
  2821  SCQPYRSAFY ILEQQCVGLA VDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL
  2881  DRCYSTPSGY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QGPPCPRLSR
  2941  ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG
  3001  KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLSRELLDEK GPEVLQDSLD RCYSTPSGCL
  3061  ELTDSCQPYR SAFYILEQQC VGLAVDMDEI EKYQEVEEDQ DPSCPRLSRE LLAEKEPEVL
  3121  QDPLDRCYST PSGYLELPDL GQPYSSAVYS LEEQYLGLAL DVDRIKKDQE EEEDQGPPCP
  3181  RLSRELLEVV EPEVLQDSLD RCYSTPSSCL EQPDSCQPYG SSFYALEEKH VGFSLDVGEI
  3241  EKKGKGKKRR GRRSKKERRR GRKEGEEDQN PPCPRLSREL LDEKGPEVLQ DSLDRCYSTP
  3301  SGCLELTDSC QPYRSAFYIL EQQCVGLAVD MDEIEKYQEV EEDQDPSCPR LSRELLAEKE
  3361  PEVLQDPLDR CYSTPSGYLE LPDLGQPYSS AVYSLEEQYL GLALDVDRIK KDQEEEEDQG
  3421  PPCPRLSREL LEVVEPEVLQ DSLDRCYSTP SSCLEQPDSC QPYGSSFYAL EEKHVGFSLD
  3481  VGEIEKKGKG KKRRGRRSKK ERRRGRKEGE EDQNPPCPRL SRELLDEKGP EVLQDSLDRC
  3541  YSTPSGCLEL TDSCQPYRSA FYILEQQCVG LAVDMDEIEK YQEVEEDQDP SCPRLSRELL
  3601  AEKEPEVLQD PLDRCYSTPS GYLELPDLGQ PYSSAVYSLE EQYLGLALDV DRIKKDQEEE
  3661  EDQGPPCPRL SRELLEVVEP EVLQDSLDRC YSTPSSCLEQ PDSCQPYGSS FYALEEKHVG
  3721  FSLDVGEIEK KGKGKKRRGR RSKKERRRGR KEGEEDQNPP CPRLNSVLME VEEPEVLQDS
  3781  LDGCYSTPSM YFELPDSFQH YRSVFYSFEE EHISFALYLD NRFFTLTVTS LHLVFQMLVI
  3841  FPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NBPF19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • skin: 58 nTPM
  • bone marrow: 50 nTPM
  • retina: 50 nTPM
  • ovary: 37 nTPM
  • adipose tissue: 33 nTPM
  • spleen: 33 nTPM

Single-cell type

  • podocytes: 95 nCPM
  • astrocytes: 34 nCPM
  • renal connecting tubule cells: 33 nCPM
  • renal collecting duct principal cells: 32 nCPM
  • loop of henle epithelial cells: 30 nCPM
  • bergmann glia: 29 nCPM

Immune cell

  • classical monocyte: 26 nTPM
  • neutrophil: 25 nTPM
  • basophil: 24 nTPM
  • plasmacytoid DC: 17 nTPM
  • NK-cell: 11 nTPM
  • intermediate monocyte: 8.8 nTPM

Brain region

  • choroid plexus: 118 nTPM
  • cerebral cortex: 113 nTPM
  • thalamus: 86 nTPM
  • amygdala: 68 nTPM
  • midbrain: 66 nTPM
  • hippocampal formation: 61 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NBPF19 as an antibody target. Whether an autoantibody or antibody against NBPF19 could matter depends on whether native NBPF19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NBPF19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NBPF19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NBPF19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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