Seroatlas · Human Serome Atlas

NBPF15

NBPF family member NBPF15

Also known as: MGC8902, NBPF16, NBPFF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N660
Gene: NBPF15
Ensembl: ENSG00000266338
Chromosome: 1
Canonical length: 670 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles,Microtubules,Cytokinetic bridge,Primary cilium,Cytosol,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

670 residues, UniProt reviewed canonical sequence.

>Q8N660|NBPF15
     1  MVVSAGPLSS EKAEMNILEI NEKLRPQLAE KKQQFRNLKE KCFLTQLAGF LANRQKKYKY
    61  EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH AQERELTQLR EKLREGRDAS
   121  RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLTQHLVQ KLSPENDNDD DEDVQVEVAE
   181  KVQKSSAPRE MQKAEEKEVP EDSLEECAIT CSNSHGPYDS NQPHKKTKIT FEEDKVDSTL
   241  IGSSSHVEWE DAVHIIPENE SDDEEEEEKG PVSPRNLQES EEEEVPQESW DEGYSTLSIP
   301  PEMLASYQSY SSTFHSLEEQ QVCMAVDIGR HRWDQVKKED QEATGPRLSR ELLDEKEPEV
   361  LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA IDMDEIEKYQ EVEEDQDPSC
   421  PRLSRELLDE KEPEVLQDSL DRCYSTPSDY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR
   481  IKKDQEEEED QGPPCPRLSR ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY
   541  ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKKRRRGRKE GEDDNPPCPR LYGVLMEVEE
   601  PEVLQDSLDR CYSTPSMYFE QPDSFQHYRS VFYSFEEEHI SFALYVDNRF FTLTVTSLHL
   661  VFQMGVIFPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NBPF15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 35 nTPM
liver: 28 nTPM
spleen: 22 nTPM
thyroid gland: 21 nTPM
lung: 19 nTPM
epididymis: 19 nTPM

Single-cell type

adrenal cortex cells: 59 nCPM
pituitary stem cells: 57 nCPM
podocytes: 49 nCPM
fibro-adipogenic progenitors: 47 nCPM
brain excitatory neurons: 46 nCPM
lymphatic endothelial cells: 39 nCPM

Immune cell

T-reg: 3.9 nTPM
memory CD4 T-cell: 2.9 nTPM
naive CD4 T-cell: 2.9 nTPM
memory B-cell: 2.6 nTPM
NK-cell: 2.3 nTPM
naive B-cell: 2 nTPM

Brain region

cerebellum: 27 nTPM
hypothalamus: 18 nTPM
midbrain: 16 nTPM
basal ganglia: 16 nTPM
choroid plexus: 16 nTPM
medulla oblongata: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -4.37

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NBPF15 as an antibody target. Whether an autoantibody or antibody against NBPF15 could matter depends on whether native NBPF15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NBPF15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NBPF15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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