Seroatlas · Human Serome Atlas

NBPF14

NBPF family member NBPF14

Also known as: NBPFE_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TI25
Gene: NBPF14
Canonical length: 2988 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for NBPF14 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

2988 residues, UniProt reviewed canonical sequence.

>Q5TI25|NBPF14
     1  MVVSAGPWSS EKAEMNILEI NETLRPQLAE KKQQFRNLKE KCFLTQLAGF LANQQKKYKY
    61  EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLR EKLREGRDAS
   121  RSLYEHLQAL LTPYEPDKSQ GQDLQEQLAE GCRLAQHLVQ KLSPENDEDE DEDVQVEEAE
   181  KVLESSAPRE VQKAEESKVP EDSLEECAIT CSNSHGPCDS NQPHKNIKIT FEEDEVNSTL
   241  VVDRESSHDE CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLRPQLA
   301  EKKQQFRNLK EKCFLTQLSG FLANQQKKYK YEECKDLIKF MLRNERQFKE EKLAEQLKQA
   361  EELRQYKVLV HAQERELTQL REKLREGRDA SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA
   421  EGCRLAQHLV QKLSPENDND DDEDVQVEVA EKVQKSSAPR EMQKAEEKEV PEDSLEECAI
   481  TYSNSHGSYD SNQPHRKTKI TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK
   541  GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPEMLASYQS YSSTFHSLEE QQVCMAVDIG
   601  RHRWDQVKKE DQEATGPRLS RELLDEKGPE VLQDSLDRCY STPSGCLELT DSCQPYRSAF
   661  YVLEQQRVGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLD EKEPEVLQDS LDRCYSTPSG
   721  YLELPDLGQP YSSAVYSLEE QYLGLALDVD RIKKDEEEEE DQDPPCPRLS RELLEVVEPE
   781  VLQDSLDRCY STPSSCLEQP DSCQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKKRRGRR
   841  SKKERRRGRK EGEEDQNPPC PRLSRELLDE KEPEVLQDSL DRCYSTPSGY LELPDLGQPY
   901  SSAVYSLEEQ YLGLALDVDR IKKDEEEEED QDPPCPRLSR ELLEVVEPEV LQDSLDRCYS
   961  TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG KGKKRRGRRS KKERRRGRKE
  1021  GEEDQNPPCP RLSRELLDEK GPEVLQDSLD RCYSTPSGCL ELTDSCQPYR SAFYVLEQQR
  1081  VGLAVDMDEI EKYQEVEEDQ DPSCPRLSRE LLDEKEPEVL QDSLDRCYST PSGYLELPDL
  1141  GQPYSSAVYS LEEQYLGLAL DVDRIKKDEE EEEDQDPPCP RLSRELLEVV EPEVLQDSLD
  1201  RCYSTPSSCL EQPDSCQPYG SSFYALEEKH VGFSLDVGEI EKKGKGKKRR GRRSKKERRR
  1261  GRKEGEEDQN PPCPRLSREL LDEKGPEVLQ DSLDRCYSTP SGCLELTDSC QPYRSAFYVL
  1321  EQQRVGLAVD MDEIEKYQEV EEDQDPSCPR LSRELLDEKE PEVLQDSLDR CYSTPSGYLE
  1381  LPDLGQPYSS AVYSLEEQYL GLALDVDRIK KDEEEEEDQD PPCPRLSREL LEVVEPEVLQ
  1441  DSLDRCYSTP SSCLEQPDSC QPYGSSFYAL EEKHVGFSLD VGEIEKKGKG KKRRGRRSKK
  1501  ERRRGRKEGE EDQNPPCPRL SRELLHEKGP EVLQDSLDRC YSTPSGCLEL TDSCQPYRSA
  1561  FYILEQQRVG LAVDMDEIEK YKEVEEDQDP SCPRLSRELL DEKEPEVLQD SLDRCYSTPS
  1621  GYLELPDLGQ PYSSAVYSLE EQYLGLALDV DRFKKDEEEE EDQDPPCPRL SRELLEVVEP
  1681  EVLQDSLDRC YSTPSSCLEQ PDSCQPYGSS FYALEEKHVG FSLDVGEIEK KGKGKKRRGR
  1741  RSKKERRRGR KEGEEDQNPP CPRLSRELLD EKGPEVLQDS LDRCYSTPSG CLELTDSCQP
  1801  YRSAFYVLEQ QRVGLAVDMD EIEKYKEVEE DQDPSCPRLS RELLDEKEPE VLQDSLDRCY
  1861  STPSGYLELP DLGQPYSSAV YSLEEQYLGL ALDVDRIKKD QEEEEDQGPP CPRLSRELLE
  1921  VVEPEVLQDS LDRCYSTPSS CLEQPDSCQP YGSSFYALEE KHVGFSLDVG EIEKKGKGKK
  1981  RRGRRSKKER RRGRKEGEED QNPPCPRLSR ELLDEKGPEV LQDSLDRCYS TPSGCLELTD
  2041  SCQPYRSAFY VLEQQRVGLA VDMDEIEKYK EVEEDQDPSC PRLSRELLDE KEPEVLQDSL
  2101  DRCYSTPSGY LELPDLGQPY SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QGPPCPRLSR
  2161  ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG
  2221  KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLSRELLDEK GPEVLQDSLD RCYSTPSGCL
  2281  ELTDSCQPYR SAFYVLEQQR VGLAVDMDEI EKYKEVEEDQ DPSCPRLSRE LLDEKEPEVL
  2341  QDSLDRCYST PSGYLELPDL GQPYSSAVYS LEEQYLGLAL DVDRIKKDQE EEEDQGPPCP
  2401  RLSRELLEVV EPEVLQDSLD RCYSTPSSCL EQPDSCQPYG SSFYALEEKH VGFSLDVGEI
  2461  EKKGKGKKRR GRRSKKERRR GRKEGEEDQN PPCPRLSREL LDEKGPEVLQ DSLDRCYSTP
  2521  SGCLELTDSC QPYRSAFYVL EQQRVGLAVD MDEIEKYKEV EEDQDPSCPR LSRELLDEKE
  2581  PEVLQDSLDR CYSTPSGYLE LPDLGQPYSS AVYSLEEQYL GLALDVDRIK KDQEEEEDQG
  2641  PPCPRLSREL LEVVEPEVLQ DSLDRCYSTP SSCLEQPDSC QPYGSSFYAL EEKHVGFSLD
  2701  VGEIEKKGKG KKRRGRRSKK ERRRGRKEGE EDQNPPCPRL SRELLDEKGP EVLQDSLDRC
  2761  YSTPSGCLEL TDSCQPYRSA FYVLEQQRVG LAVDMDEIEK YQEVEEDQDP SCPRLSRELL
  2821  DEKDPEVLQD SLDRCYSTPS GYLELPDLGQ PYSSAVYSLE EQYLGLALDV DKIEKKGKGK
  2881  KRRGRRSKKE RRRGRKEGEE DQNPPCPRLN GVLMEVEERE VLQDSLDRCY STPSMYFELP
  2941  DSFQHYRSVF YSFEEQHISF ALYVDNRFFT LTVTSLHLVF QMGVIFPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NBPF14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

skin: 49 nTPM
bone marrow: 41 nTPM
ovary: 40 nTPM
spleen: 30 nTPM
adipose tissue: 28 nTPM
endometrium: 27 nTPM

Single-cell type

podocytes: 91 nCPM
sertoli cells: 88 nCPM
neutrophils: 69 nCPM
suprabasal keratinocytes: 66 nCPM
leydig cells: 48 nCPM
monocytes: 43 nCPM

Immune cell

neutrophil: 44 nTPM
basophil: 43 nTPM
classical monocyte: 24 nTPM
eosinophil: 22 nTPM
plasmacytoid DC: 22 nTPM
non-classical monocyte: 17 nTPM

Brain region

choroid plexus: 99 nTPM
cerebral cortex: 78 nTPM
thalamus: 64 nTPM
hippocampal formation: 59 nTPM
medulla oblongata: 57 nTPM
white matter: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -6.43

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NBPF14 as an antibody target. Whether an autoantibody or antibody against NBPF14 could matter depends on whether native NBPF14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NBPF14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NBPF14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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