Seroatlas · Human Serome Atlas

NBPF11

NBPF family member NBPF11

Also known as: NBPF24, NBPFB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86T75
Gene: NBPF11
Ensembl: ENSG00000263956
Chromosome: 1
Canonical length: 865 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles,Cytokinetic bridge,Primary cilium,Cytosol,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

865 residues, UniProt reviewed canonical sequence.

>Q86T75|NBPF11
     1  MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFRNLKE RCFLTQLAGF LANRQKKYKY
    61  EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLR EKLREGRDAS
   121  RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE
   181  KVLESSAPRE VQKAEESKVP EDSLEECAIT CSNSHGPCDS IQPHKNIKIT FEEDKVNSSL
   241  VVDRESSHDG CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLCPQLA
   301  EKKQQFRSLK EKCFVTQVAC FLAKQQNKYK YEECKDLIKS MLRNERQFKE EKLAEQLKQA
   361  EELRQYKVLV HSQERELTQL REKLREGRDA SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA
   421  EGCRLAQHLV QKLSPENDND DDEDVQVEVA EKVQKSSSPR EMQKAEEKEV PEDSLEECAI
   481  TCSNSHGPYD SNQPHRKTKI TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK
   541  GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPERLASYQS YSSTFHSLEE QQVCMAVDIG
   601  RHRWDQVKKE DQEATGPRLS RELLDEKEPE VLQDSLDRCY STPSVYLGLT DSCQPYRSAF
   661  YVLEQQRIGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLA EKEPEVLQDS LDRCYSTPSG
   721  YLELPDLGQP YRSAVYSLEE QYLGLALDVD RIKKDQEEEE DQGPPCPRLS RELLEVVEPE
   781  VLQDSLDVIQ LLPVVLNSLT PASPTEVPFM HWRKNMLAFL LTWEKLKRRG RGRKEGEEDQ
   841  RRKEEGEEKK GKKIKTHHAP GSAAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NBPF11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

liver: 16 nTPM
epididymis: 15 nTPM
spleen: 11 nTPM
pancreas: 11 nTPM
skin: 11 nTPM
ovary: 11 nTPM

Single-cell type

adrenal cortex cells: 73 nCPM
pituicytes/fscs: 71 nCPM
pituitary stem cells: 71 nCPM
hepatocytes: 66 nCPM
bergmann glia: 57 nCPM
adipocytes: 54 nCPM

Immune cell

basophil: 2.4 nTPM
eosinophil: 2.1 nTPM
plasmacytoid DC: 1.6 nTPM
naive B-cell: 1.5 nTPM
gdT-cell: 1.2 nTPM
non-classical monocyte: 1.2 nTPM

Brain region

white matter: 12 nTPM
medulla oblongata: 11 nTPM
cerebral cortex: 10 nTPM
pons: 9.8 nTPM
thalamus: 9.4 nTPM
choroid plexus: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: -1.26

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NBPF11 as an antibody target. Whether an autoantibody or antibody against NBPF11 could matter depends on whether native NBPF11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NBPF11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NBPF11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...