Seroatlas · Human Serome Atlas

NBEAP1

Putative protein BCL8

Also known as: BCL8_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C6P0
Gene: NBEAP1
Canonical length: 100 aa

OverviewNCBI Gene

No narrative summary is available for NBEAP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

100 residues, UniProt reviewed canonical sequence.

>P0C6P0|NBEAP1
     1  MSCCLSSRVH ITRPVLEQFL SFAKYLDGLS HGVPLLKQLC DHILFINPAI WIHTPAKVQL
    61  SLYTYLSAEF IGTATIYTTI CRIGTVIKDN AHLKILLLGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NBEAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Chromosomal rearrangement

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NBEAP1 as an antibody target. Whether an autoantibody or antibody against NBEAP1 could matter depends on whether native NBEAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NBEAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NBEAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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