NAT2

Protein identityUniProt · HPA

UniProt accession

P11245

Gene

NAT2

Ensembl

ENSG00000156006

Chromosome

8

Canonical length

290 aa

Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2). [provided by RefSeq, Sep 2019]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>P11245|NAT2
     1  MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL GLEAIFDHIV
    61  RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK YSTGMVHLLL QVTIDGRNYI
   121  VDAGSGSSSQ MWQPLELISG KDQPQVPCIF CLTEERGIWY LDQIRREQYI TNKEFLNSHL
   181  LPKKKHQKIY LFTLEPRTIE DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT
   241  YRKFNYKDNT DLVEFKTLTE EEVEEVLRNI FKISLGRNLV PKPGDGSLTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

120 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.79

gnomAD pLI

0

gnomAD missense Z

-1.38

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• xenobiotic metabolic process

Molecular functions

• arylamine N-acetyltransferase activity
• N-hydroxyarylamine O-acetyltransferase activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Arylamine N-acetyltransferase
• Papain-like cysteine peptidase superfamily
• Arylamine N-acetyltransferase domain-containing protein
• N-acetyltransferase

KeywordsUniProt

• Acyltransferase
• Cytoplasm
• Transferase

InteractionsUniProt · HPA

Protein binding partners of NAT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATM
• RAD51