Seroatlas · Human Serome Atlas

NANOS3

Nanos homolog 3

Also known as: NANO3_HUMAN, NANOS1L, NOS3, ZC2HC12C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60323
Gene: NANOS3
Ensembl: ENSG00000187556
Chromosome: 19
Canonical length: 173 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables enzyme activator activity. Involved in germ cell development; mRNA destabilization; and negative regulation of translation. Located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>P60323|NANOS3
     1  MGTFDLWTDY LGLAHLVRAL SGKEGPETRL SPQPEPEPML EPDQKRSLES SPAPERLCSF
    61  CKHNGESRAI YQSHVLKDEA GRVLCPILRD YVCPQCGATR ERAHTRRFCP LTGQGYTSVY
   121  SHTTRNSAGK KLVRPDKAKT QDTGHRRGGG GGAGFRGAGK SEPSPSCSPS MST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NANOS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 3.5 nTPM

Expression across tissuesHPA

Tissue

testis: 3.5 nTPM
cerebellum: 2.7 nTPM
cerebral cortex: 2.6 nTPM
hypothalamus: 1 nTPM
amygdala: 0.9 nTPM
hippocampal formation: 0.8 nTPM

Single-cell type

undifferentiated spermatogonia: 17 nCPM
other brain neurons: 9.4 nCPM
brain excitatory neurons: 8.2 nCPM
differentiating spermatogonia: 8.2 nCPM
brain inhibitory neurons: 7.3 nCPM
oligodendrocyte progenitor cells: 5.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 5 nTPM
cerebellum: 3.6 nTPM
white matter: 2.9 nTPM
basal ganglia: 2.4 nTPM
pons: 2.4 nTPM
hypothalamus: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0.04
gnomAD missense Z: 1.35
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NANOS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PUM2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NANOS3 as an antibody target. Whether an autoantibody or antibody against NANOS3 could matter depends on whether native NANOS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NANOS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NANOS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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