Seroatlas · Human Serome Atlas

NAIF1

Nuclear apoptosis-inducing factor 1

Also known as: bA379C10.2, C9orf90, DKFZp762G199, NAIF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q69YI7
Gene: NAIF1
Ensembl: ENSG00000171169
Chromosome: 9
Canonical length: 327 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Involved in negative regulation of cell growth and regulation of mitochondrial membrane permeability involved in apoptotic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q69YI7|NAIF1
     1  MAVPAKKRKM NFSEREVEII VEELELKKHL LVNHFNAGVP LAAKSAAWHG ILRRVNAVAT
    61  CRRELPEVKK KWSDLKTEVR RKVAQVRAAV EGGEAPGPTE EDGAGGPGTG GGSGGGGPAV
   121  APVLLTPMQQ RICNLLGEAT IISLPSTTEI HPVALGPSAT AAAATVTLTQ IPTETTYHTL
   181  EEGVVEYCTA EAPPPLPPET PVDMMAQHAD TSVKPQALKS RIALNSAKLI QEQRVTNLHV
   241  KEIAQHLEQQ NDLLQMIRRS QEVQACAQER QAQAMEGTQA ALSVLIQVLR PMIKDFRRYL
   301  QSNTANPAPA SDPGQVAQNG QPDSIIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAIF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 4 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 4 nTPM
testis: 3.2 nTPM
spleen: 3 nTPM
esophagus: 2.5 nTPM
liver: 2.5 nTPM
skeletal muscle: 2.5 nTPM

Single-cell type

late primary spermatocytes: 21 nCPM
esophageal apical cells: 20 nCPM
late spermatids: 18 nCPM
kupffer cells: 13 nCPM
differentiating spermatogonia: 12 nCPM
epididymal basal cells: 12 nCPM

Immune cell

neutrophil: 1.5 nTPM
eosinophil: 1.1 nTPM
memory CD4 T-cell: 1.1 nTPM
non-classical monocyte: 1 nTPM
naive B-cell: 0.9 nTPM
classical monocyte: 0.7 nTPM

Brain region

thalamus: 3.9 nTPM
basal ganglia: 3.5 nTPM
medulla oblongata: 3.4 nTPM
choroid plexus: 3.3 nTPM
pons: 3.2 nTPM
cerebellum: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.29
gnomAD missense Z: 2.17
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAIF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HARBI1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAIF1 as an antibody target. Whether an autoantibody or antibody against NAIF1 could matter depends on whether native NAIF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAIF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAIF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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