Seroatlas · Human Serome Atlas

HARBI1

Putative nuclease HARBI1

Also known as: C11orf77, FLJ32675, HARB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MB7
Gene: HARBI1
Ensembl: ENSG00000180423
Chromosome: 11
Canonical length: 349 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable metal ion binding activity and nuclease activity. Located in centriolar satellite; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q96MB7|HARBI1
     1  MAIPITVLDC DLLLYGRGHR TLDRFKLDDV TDEYLMSMYG FPRQFIYYLV ELLGANLSRP
    61  TQRSRAISPE TQVLAALGFY TSGSFQTRMG DAIGISQASM SRCVANVTEA LVERASQFIR
   121  FPADEASIQA LKDEFYGLAG MPGVMGVVDC IHVAIKAPNA EDLSYVNRKG LHSLNCLMVC
   181  DIRGTLMTVE TNWPGSLQDC AVLQQSSLSS QFEAGMHKDS WLLGDSSFFL RTWLMTPLHI
   241  PETPAEYRYN MAHSATHSVI EKTFRTLCSR FRCLDGSKGA LQYSPEKSSH IILACCVLHN
   301  ISLEHGMDVW SSPMTGPMEQ PPEEEYEHME SLDLEADRIR QELMLTHFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HARBI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
bone marrow: 5.1 nTPM
thymus: 3.9 nTPM
stomach: 3.8 nTPM
lymph node: 3.2 nTPM
rectum: 3.2 nTPM

Single-cell type

late spermatids: 110 nCPM
cardiomyocytes: 93 nCPM
early spermatids: 92 nCPM
epicardial cells: 46 nCPM
late primary spermatocytes: 35 nCPM
early primary spermatocytes: 20 nCPM

Immune cell

basophil: 22 nTPM
neutrophil: 11 nTPM
eosinophil: 11 nTPM
intermediate monocyte: 10 nTPM
T-reg: 10 nTPM
non-classical monocyte: 9.8 nTPM

Brain region

white matter: 18 nTPM
cerebral cortex: 12 nTPM
basal ganglia: 12 nTPM
thalamus: 11 nTPM
medulla oblongata: 11 nTPM
pons: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Harbinger transposase-derived nuclease, animal
Harbinger transposase-derived nuclease domain
Putative nuclease HARBI1-like
DDE superfamily endonuclease

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HARBI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NAIF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HARBI1 as an antibody target. Whether an autoantibody or antibody against HARBI1 could matter depends on whether native HARBI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HARBI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HARBI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...