Seroatlas · Human Serome Atlas

NAB2

NGFI-A-binding protein 2

Also known as: MADER, NAB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15742
Gene: NAB2
Ensembl: ENSG00000166886
Chromosome: 12
Canonical length: 525 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homomultimer

OverviewNCBI Gene

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>Q15742|NAB2
     1  MHRAPSPTAE QPPGGGDSAR RTLQPRLKPS ARAMALPRTL GELQLYRVLQ RANLLSYYET
    61  FIQQGGDDVQ QLCEAGEEEF LEIMALVGMA TKPLHVRRLQ KALREWATNP GLFSQPVPAV
   121  PVSSIPLFKI SETAGTRKGS MSNGHGSPGE KAGSARSFSP KSPLELGEKL SPLPGGPGAG
   181  DPRIWPGRST PESDVGAGGE EEAGSPPFSP PAGGGVPEGT GAGGLAAGGT GGGPDRLEPE
   241  MVRMVVESVE RIFRSFPRGD AGEVTSLLKL NKKLARSVGH IFEMDDNDSQ KEEEIRKYSI
   301  IYGRFDSKRR EGKQLSLHEL TINEAAAQFC MRDNTLLLRR VELFSLSRQV ARESTYLSSL
   361  KGSRLHPEEL GGPPLKKLKQ EVGEQSHPEI QQPPPGPESY VPPYRPSLEE DSASLSGESL
   421  DGHLQAVGSC PRLTPPPADL PLALPAHGLW SRHILQQTLM DEGLRLARLV SHDRVGRLSP
   481  CVPAKPPLAE FEEGLLDRCP APGPHPALVE GRRSSVKVEA EASRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 58 nTPM
ovary: 53 nTPM
blood vessel: 40 nTPM
cervix: 38 nTPM
pituitary gland: 36 nTPM
endometrium: 35 nTPM

Single-cell type

syncytiotrophoblasts: 62 nCPM
decidual stromal cells: 50 nCPM
breast secretory cells: 37 nCPM
pituicytes/fscs: 37 nCPM
epididymal basal cells: 34 nCPM
epididymal principal cells: 29 nCPM

Immune cell

non-classical monocyte: 3 nTPM
intermediate monocyte: 2.7 nTPM
naive B-cell: 2.3 nTPM
naive CD8 T-cell: 1.2 nTPM
classical monocyte: 1.1 nTPM
naive CD4 T-cell: 1.1 nTPM

Brain region

cerebellum: 31 nTPM
cerebral cortex: 31 nTPM
hippocampal formation: 28 nTPM
basal ganglia: 24 nTPM
hypothalamus: 21 nTPM
amygdala: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.57
gnomAD missense Z: 3.01
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RFC5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAB2 as an antibody target. Whether an autoantibody or antibody against NAB2 could matter depends on whether native NAB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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