MYOZ3
Myozenin-3
Also known as: CS-3, CS3, FATZ-3, FRP3, MYOZ3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TDC0
- Gene
- MYOZ3
- Ensembl
- ENSG00000164591
- Chromosome
- 5
- Canonical length
- 251 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
The protein encoded by this gene is specifically expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]
Canonical amino-acid sequenceUniProt
251 residues, UniProt reviewed canonical sequence.
>Q8TDC0|MYOZ3
1 MIPKEQKGPV MAAMGDLTEP VPTLDLGKKL SVPQDLMMEE LSLRNNRGSL LFQKRQRRVQ
61 KFTFELAASQ RAMLAGSARR KVTGTAESGT VANANGPEGP NYRSELHIFP ASPGASLGGP
121 EGAHPAAAPA GCVPSPSALA PGYAEPLKGV PPEKFNHTAI SKGYRCPWQE FVSYRDYQSD
181 GRSHTPSPND YRNFNKTPVP FGGPLVGGTF PRPGTPFIPE PLSGLELLRL RPSFNRVAQG
241 WVRNLPESEE LLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MYOZ3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 219 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 219 nTPM
- tongue: 185 nTPM
- esophagus: 5.1 nTPM
- heart muscle: 5 nTPM
- hypothalamus: 4.6 nTPM
- prostate: 3.9 nTPM
Single-cell type
- myonuclei: 165 nCPM
- peritubular myoid cells: 63 nCPM
- epididymal basal cells: 13 nCPM
- thymic myoid cells: 12 nCPM
- podocytes: 9.8 nCPM
- hematopoietic stem cells: 9.2 nCPM
Immune cell
- plasmacytoid DC: 0.3 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- medulla oblongata: 19 nTPM
- spinal cord: 14 nTPM
- pons: 7.9 nTPM
- thalamus: 7.4 nTPM
- white matter: 7.4 nTPM
- midbrain: 7.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.39
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.26
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MYOZ3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MYOZ3 as an antibody target. Whether an autoantibody or antibody against MYOZ3 could matter depends on whether native MYOZ3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MYOZ3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MYOZ3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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