Seroatlas · Human Serome Atlas

MYOM3

Myomesin-3

Also known as: FLJ35961, MYOM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VTT5
Gene
MYOM3
Ensembl
ENSG00000142661
Chromosome
1
Canonical length
1437 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Cytokinetic bridge
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable protein homodimerization activity. Predicted to be involved in sarcomere organization. Predicted to be located in cytoplasm. Predicted to be active in M band. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1437 residues, UniProt reviewed canonical sequence.

>Q5VTT5|MYOM3
     1  MTLPHSLGGA GDPRPPQAME VHRLEHRQEE EQKEERQHSL RMGSSVRRRT FRSSEEEHEF
    61  SAADYALAAA LALTASSELS WEAQLRRQTS AVELEERGQK RVGFGNDWER TEIAFLQTHR
   121  LLRQRRDWKT LRRRTEEKVQ EAKELRELCY GRGPWFWIPL RSHAVWEHTT VLLTCTVQAS
   181  PPPQVTWYKN DTRIDPRLFR AGKYRITNNY GLLSLEIRRC AIEDSATYTV RVKNAHGQAS
   241  SFAKVLVRTY LGKDAGFDSE IFKRSTFGPS VEFTSVLKPV FAREKEPFSL SCLFSEDVLD
   301  AESIQWFRDG SLLRSSRRRK ILYTDRQASL KVSCTYKEDE GLYMVRVPSP FGPREQSTYV
   361  LVRDAEAENP GAPGSPLNVR CLDVNRDCLI LTWAPPSDTR GNPITAYTIE RCQGESGEWI
   421  ACHEAPGGTC RCPIQGLVEG QSYRFRVRAI SRVGSSVPSK ASELVVMGDH DAARRKTEIP
   481  FDLGNKITIS TDAFEDTVTI PSPPTNVHAS EIREAYVVLA WEEPSPRDRA PLTYSLEKSV
   541  IGSGTWEAIS SESPVRSPRF AVLDLEKKKS YVFRVRAMNQ YGLSDPSEPS EPIALRGPPA
   601  TLPPPAQVQA FRDTQTSVSL TWDPVKDPEL LGYYIYSRKV GTSEWQTVNN KPIQGTRFTV
   661  PGLRTGKEYE FCVRSVSEAG VGESSAATEP IRVKQALATP SAPYGFALLN CGKNEMVIGW
   721  KPPKRRGGGK ILGYFLDQHD SEELDWHAVN QQPIPTRVCK VSDLHEGHFY EFRARAANWA
   781  GVGELSAPSS LFECKEWTMP QPGPPYDVRA SEVRATSLVL QWEPPLYMGA GPVTGYHVSF
   841  QEEGSEQWKP VTPGPISGTH LRVSDLQPGK SYVFQVQAMN SAGLGQPSMP TDPVLLEDKP
   901  GAHEIEVGVD EEGFIYLAFE APEAPDSSEF QWSKDYKGPL DPQRVKIEDK VNKSKVILKE
   961  PGLEDLGTYS VIVTDADEDI SASHTLTEEE LEKLKKLSHE IRNPVIKLIS GWNIDILERG
  1021  EVRLWLEVEK LSPAAELHLI FNNKEIFSSP NRKINFDREK GLVEVIIQNL SEEDKGSYTA
  1081  QLQDGKAKNQ ITLTLVDDDF DKLLRKADAK RRDWKRKQGP YFERPLQWKV TEDCQVQLTC
  1141  KVTNTKKETR FQWFFQRAEM PDGQYDPETG TGLLCIEELS KKDKGIYRAM VSDDRGEDDT
  1201  ILDLTGDALD AIFTELGRIG ALSATPLKIQ GTEEGIRIFS KVKYYNVEYM KTTWFHKDKR
  1261  LESGDRIRTG TTLDEIWLHI LDPKDSDKGK YTLEIAAGKE VRQLSTDLSG QAFEDAMAEH
  1321  QRLKTLAIIE KNRAKVVRGL PDVATIMEDK TLCLTCIVSG DPTPEISWLK NDQPVTFLDR
  1381  YRMEVRGTEV TITIEKVNSE DSGRYGVFVK NKYGSETGQV TISVFKHGDE PKELKSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYOM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
309 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 309 nTPM
  • tongue: 239 nTPM
  • heart muscle: 210 nTPM
  • kidney: 29 nTPM
  • testis: 8.7 nTPM
  • salivary gland: 7 nTPM

Single-cell type

  • myonuclei: 686 nCPM
  • cardiomyocytes: 227 nCPM
  • thymic myoid cells: 173 nCPM
  • proximal tubule cells: 78 nCPM
  • sertoli cells: 78 nCPM
  • enterocytes: 41 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 1.1 nTPM
  • medulla oblongata: 0.9 nTPM
  • white matter: 0.9 nTPM
  • hypothalamus: 0.8 nTPM
  • cerebral cortex: 0.7 nTPM
  • midbrain: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
-0.65
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYOM3 as an antibody target. Whether an autoantibody or antibody against MYOM3 could matter depends on whether native MYOM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYOM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYOM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MYOM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...