Seroatlas · Human Serome Atlas

MYBPHL

Myosin-binding protein H-like

Also known as: MBPHL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2RUH7
Gene: MYBPHL
Ensembl: ENSG00000221986
Chromosome: 1
Canonical length: 354 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a protein with two immunoglobulin superfamily domains and a fibronectin 3 domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>A2RUH7|MYBPHL
     1  MEAATAPEVA AGSKLKVKEA SPADAEPPQA SPGQGAGSPT PQLLPPIEEH PKIWLPRALR
    61  QTYIRKVGDT VNLLIPFQGK PKPQAIWTHD GCALDTRRVS VRNGEQDSIL FIREAQRADS
   121  GRYQLRVQLG GLEATATIDI LVIERPGPPQ SIKLVDVWGF SATLEWTPPQ DTGNTALLGY
   181  TVQKADTKSG LWFTVLEHYH RTSCIVSDLI IGNSYAFRVF AENQCGLSET APITTDLAHI
   241  QKAATVYKTK GFAQRDFSEA PKFTQPLADC TTVTGYNTQL FCCVRASPRP KIIWLKNKMD
   301  IQGNPKYRAL THLGICSLEI RKPGPFDGGI YTCKAVNPLG EASVDCRVDV KVPN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYBPHL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 101 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 101 nTPM
pituitary gland: 2.8 nTPM
fallopian tube: 2.2 nTPM
retina: 1.9 nTPM
lung: 1.1 nTPM
hippocampal formation: 1 nTPM

Single-cell type

rod photoreceptor cells: 18 nCPM
myosatellite cells: 9 nCPM
corticotrophs: 6.8 nCPM
mesothelial cells: 5.5 nCPM
podocytes: 4.6 nCPM
alveolar cells type 2: 4.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 6.2 nTPM
white matter: 5.5 nTPM
hippocampal formation: 5.1 nTPM
basal ganglia: 3.1 nTPM
medulla oblongata: 2 nTPM
midbrain: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

in utero embryonic development

Cellular components

sarcomere
myofilament

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYBPHL as an antibody target. Whether an autoantibody or antibody against MYBPHL could matter depends on whether native MYBPHL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYBPHL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYBPHL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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