Seroatlas · Human Serome Atlas

MYBPH

Myosin-binding protein H

Also known as: MYBPH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13203
Gene: MYBPH
Ensembl: ENSG00000133055
Chromosome: 1
Canonical length: 477 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Mitochondria

OverviewNCBI Gene

Predicted to be a structural constituent of muscle. Predicted to be involved in sarcomere organization. Predicted to be located in myosin filament. Predicted to be active in M band. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>Q13203|MYBPH
     1  MMEKNTSEGP ACSPEETASE SAKVPTAEPP GEVAVSESTR EEQVPKPQAP APQAPTASTA
    61  TKPAPPSEDV PSAPLLLTLD DVSSSSVTVS WEPPERLGRL GLQGYVLELC REGASEWVPV
   121  SARPMMVTQQ TVRNLALGDK FLLRVSAVSS AGAGPPAMLD QPIHIRENIE APKIRVPRHL
   181  RQTYIRQVGE TVNLQIPFQG KPKPQATWTH NGHALDSQRV SMRTGDQDSI LFIRSAQRSD
   241  SGRYELTVRV EDLEAKAVID ILVIEKPGPP SSIRLLDVWG CNAALQWTPP QDTGNTELLG
   301  YMVQKADKKT GQWFTVLERY HPTTCTISDL IIGNSYSFRV FSENLCGLST SATVTKELAH
   361  IQKADIAAKP KGFIERDFSE APSFTQPLAD HTSTPGYSTQ LFCSVRASPK PKIIWMKNKM
   421  EIQGNPKYRA LSEQGVCTLE IRKPSPFDSG VYTCKAINVL GEASVDCRLE VKASAAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYBPH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 73 nTPM
tongue: 18 nTPM
salivary gland: 17 nTPM
choroid plexus: 4.9 nTPM
liver: 4.7 nTPM
prostate: 3.1 nTPM

Single-cell type

thymic myoid cells: 393 nCPM
myonuclei: 6.7 nCPM
podocytes: 6.2 nCPM
pdcs: 2.5 nCPM
microglia: 1.9 nCPM
breast secretory cells: 1.3 nCPM

Immune cell

plasmacytoid DC: 2.5 nTPM
intermediate monocyte: 0.4 nTPM
non-classical monocyte: 0.2 nTPM
classical monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

pons: 12 nTPM
thalamus: 12 nTPM
cerebral cortex: 9.7 nTPM
medulla oblongata: 8.9 nTPM
midbrain: 8.8 nTPM
basal ganglia: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of muscle

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYBPH as an antibody target. Whether an autoantibody or antibody against MYBPH could matter depends on whether native MYBPH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYBPH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYBPH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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