Seroatlas · Human Serome Atlas

MUC6

Mucin-6

Also known as: MUC6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6W4X9
Gene: MUC6
Ensembl: ENSG00000184956
Chromosome: 11
Canonical length: 2439 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to digestive system

OverviewNCBI Gene

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

2439 residues, UniProt reviewed canonical sequence.

>Q6W4X9|MUC6
     1  MVQRWLLLSC CGALLSAGLA NTSYTSPGLQ RLKDSPQTAP DKGQCSTWGA GHFSTFDHHV
    61  YDFSGTCNYI FAATCKDAFP TFSVQLRRGP DGSISRIIVE LGASVVTVSE AIISVKDIGV
   121  ISLPYTSNGL QITPFGQSVR LVAKQLELEL EVVWGPDSHL MVLVERKYMG QMCGLCGNFD
   181  GKVTNEFVSE EGKFLEPHKF AALQKLDDPG EICTFQDIPS THVRQAQHAR ICTQLLTLVA
   241  PECSVSKEPF VLSCQADVAA APQPGPQNSS CATLSEYSRQ CSMVGQPVRR WRSPGLCSVG
   301  QCPANQVYQE CGSACVKTCS NPQHSCSSSC TFGCFCPEGT VLNDLSNNHT CVPVTQCPCV
   361  LHGAMYAPGE VTIAACQTCR CTLGRWVCTE RPCPGHCSLE GGSFVTTFDA RPYRFHGTCT
   421  YILLQSPQLP EDGALMAVYD KSGVSHSETS LVAVVYLSRQ DKIVISQDEV VTNNGEAKWL
   481  PYKTRNITVF RQTSTHLQMA TSFGLELVVQ LRPIFQAYVT VGPQFRGQTR GLCGNFNGDT
   541  TDDFTTSMGI AEGTASLFVD SWRAGNCPAA LERETDPCSM SQLNKVCAET HCSMLLRTGT
   601  VFERCHATVN PAPFYKRCVY QACNYEETFP HICAALGDYV HACSLRGVLL WGWRSSVDNC
   661  TIPCTGNTTF SYNSQACERT CLSLSDRATE CHHSAVPVDG CNCPDGTYLN QKGECVRKAQ
   721  CPCILEGYKF ILAEQSTVIN GITCHCINGR LSCPQRPQMF LASCQAPKTF KSCSQSSENK
   781  FGAACAPTCQ MLATGVACVP TKCEPGCVCA EGLYENADGQ CVPPEECPCE FSGVSYPGGA
   841  ELHTDCRTCS CSRGRWACQQ GTHCPSTCTL YGEGHVITFD GQRFVFDGNC EYILATDVCG
   901  VNDSQPTFKI LTENVICGNS GVTCSRAIKI FLGGLSVVLA DRNYTVTGEE PHVQLGVTPG
   961  ALSLVVDISI PGRYNLTLIW NRHMTILIRI ARASQDPLCG LCGNFNGNMK DDFETRSRYV
  1021  ASSELELVNS WKESPLCGDV SFVTDPCSLN AFRRSWAERK CSVINSQTFA TCHSKVYHLP
  1081  YYEACVRDAC GCDSGGDCEC LCDAVAAYAQ ACLDKGVCVD WRTPAFCPIY CGFYNTHTQD
  1141  GHGEYQYTQE ANCTWHYQPC LCPSQPQSVP GSNIEGCYNC SQDEYFDHEE GVCVPCMPPT
  1201  TPQPPTTPQL PTTGSRPTQV WPMTGTSTTI GLLSSTGPSP SSNHTPASPT QTPLLPATLT
  1261  SSKPTASSGE PPRPTTAVTP QATSGLPPTA TLRSTATKPT VTQATTRATA STASPATTST
  1321  AQSTTRTTMT LPTPATSGTS PTLPKSTNQE LPGTTATQTT GPRPTPASTT GPTTPQPGQP
  1381  TRPTATETTQ TRTTTEYTTP QTPHTTHSPP TAGSPVPSTG PVTATSFHAT TTYPTPSHPE
  1441  TTLPTHVPPF STSLVTPSTH TVITPTHAQM ATSASNHSAP TGTIPPPTTL KATGSTHTAP
  1501  PITPTTSGTS QAHSSFSTNK TPTSLHSHTS STHHPEVTPT STTTITPNPT STRTRTPVAH
  1561  TNSATSSRPP PPFTTHSPPT GSSPFSSTGP MTATSFKTTT TYPTPSHPQT TLPTHVPPFS
  1621  TSLVTPSTHT VITPTHAQMA TSASIHSMPT GTIPPPTTLK ATGSTHTAPT MTLTTSGTSQ
  1681  ALSSLNTAKT STSLHSHTSS THHAEATSTS TTNITPNPTS TGTPPMTVTT SGTSQSRSSF
  1741  STAKTSTSLH SHTSSTHHPE VTSTSTTSIT PNHTSTGTRT PVAHTTSATS SRLPTPFTTH
  1801  SPPTGTTPIS STGPVTATSF QTTTTYPTPS HPHTTLPTHV PSFSTSLVTP STHTVIIPTH
  1861  TQMATSASIH SMPTGTIPPP TTIKATGSTH TAPPMTPTTS GTSQSPSSFS TAKTSTSLPY
  1921  HTSSTHHPEV TPTSTTNITP KHTSTGTRTP VAHTTSASSS RLPTPFTTHS PPTGSSPFSS
  1981  TGPMTATSFQ TTTTYPTPSH PQTTLPTHVP PFSTSLVTPS THTVIITTHT QMATSASIHS
  2041  TPTGTVPPPT TLKATGSTHT APPMTVTTSG TSQTHSSFST ATASSSFISS SSWLPQNSSS
  2101  RPPSSPITTQ LPHLSSATTP VSTTNQLSSS FSPSPSAPST VSSYVPSSHS SPQTSSPSVG
  2161  TSSSFVSAPV HSTTLSSGSH SSLSTHPTTA SVSASPLFPS SPAASTTIRA TLPHTISSPF
  2221  TLSALLPIST VTVSPTPSSH LASSTIAFPS TPRTTASTHT APAFSSQSTT SRSTSLTTRV
  2281  PTSGFVSLTS GVTGIPTSPV TNLTTRHPGP TLSPTTRFLT SSLTAHGSTP ASAPVSSLGT
  2341  PTPTSPGVCS VREQQEEITF KGCMANVTVT RCEGACISAA SFNIITQQVD ARCSCCRPLH
  2401  SYEQQLELPC PDPSTPGRRL VLTLQVFSHC VCSSVACGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MUC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 397 nTPM

Expression across tissuesHPA

Tissue

stomach: 397 nTPM
pancreas: 167 nTPM
seminal vesicle: 27 nTPM
duodenum: 15 nTPM
cervix: 13 nTPM
liver: 5.6 nTPM

Single-cell type

mucous neck cells: 38 nCPM
pancreatic duct cells: 19 nCPM
gastric chief cells: 19 nCPM
loop of henle epithelial cells: 8.6 nCPM
renal collecting duct principal cells: 8 nCPM
distal convoluted tubule cells: 7.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 4.5 nTPM
basal ganglia: 3.1 nTPM
hippocampal formation: 3.1 nTPM
cerebral cortex: 2.7 nTPM
cerebellum: 2.2 nTPM
hypothalamus: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.91
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

maintenance of gastrointestinal epithelium

Molecular functions

extracellular matrix structural constituent

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MUC6 as an antibody target. Whether an autoantibody or antibody against MUC6 could matter depends on whether native MUC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MUC6 is annotated as secreted, so native MUC6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MUC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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