Seroatlas · Human Serome Atlas

MTUS1

Microtubule-associated tumor suppressor 1

Also known as: ATBP, ATIP1, ATIP3, DKFZp586D1519, FLJ14295, ICIS, KIAA1288, MP44, MTSG1, MTUS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULD2
Gene: MTUS1
Ensembl: ENSG00000129422
Chromosome: 8
Canonical length: 1270 aa
Protein class: Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Microtubules
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1270 residues, UniProt reviewed canonical sequence.

>Q9ULD2|MTUS1
     1  MTDDNSDDKI EDELQTFFTS DKDGNTHAYN PKSPPTQNSS ASSVNWNSAN PDDMVVDYET
    61  DPAVVTGENI SLSLQGVEVF GHEKSSSDFI SKQVLDMHKD SICQCPALVG TEKPKYLQHS
   121  CHSLEAVEGQ SVEPSLPFVW KPNDNLNCAG YCDALELNQT FDMTVDKVNC TFISHHAIGK
   181  SQSFHTAGSL PPTGRRSGST SSLSYSTWTS SHSDKTHARE TTYDRESFEN PQVTPSEAQD
   241  MTYTAFSDVV MQSEVFVSDI GNQCACSSGK VTSEYTDGSQ QRLVGEKETQ ALTPVSDGME
   301  VPNDSALQEF FCLSHDESNS EPHSQSSYRH KEMGQNLRET VSYCLIDDEC PLMVPAFDKS
   361  EAQVLNPEHK VTETEDTQMV SKGKDLGTQN HTSELILSSP PGQKVGSSFG LTWDANDMVI
   421  STDKTMCMST PVLEPTKVTF SVSPIEATEK CKKVEKGNRG LKNIPDSKEA PVNLCKPSLG
   481  KSTIKTNTPI GCKVRKTEII SYPRPNFKNV KAKVMSRAVL QPKDAALSKV TPRPQQTSAS
   541  SPSSVNSRQQ TVLSRTPRSD LNADKKAEIL INKTHKQQFN KLITSQAVHV TTHSKNASHR
   601  VPRTTSAVKS NQEDVDKASS SNSACETGSV SALFQKIKGI LPVKMESAEC LEMTYVPNID
   661  RISPEKKGEK ENGTSMEKQE LKQEIMNETF EYGSLFLGSA SKTTTTSGRN ISKPDSCGLR
   721  QIAAPKAKVG PPVSCLRRNS DNRNPSADRA VSPQRIRRVS SSGKPTSLKT AQSSWVNLPR
   781  PLPKSKASLK SPALRRTGST PSIASTHSEL STYSNNSGNA AVIKYEEKPP KPAFQNGSSG
   841  SFYLKPLVSR AHVHLMKTPP KGPSRKNLFT ALNAVEKSRQ KNPRSLCIQP QTAPDALPPE
   901  KTLELTQYKT KCENQSGFIL QLKQLLACGN TKFEALTVVI QHLLSEREEA LKQHKTLSQE
   961  LVNLRGELVT ASTTCEKLEK ARNELQTVYE AFVQQHQAEK TERENRLKEF YTREYEKLRD
  1021  TYIEEAEKYK MQLQEQFDNL NAAHETSKLE IEASHSEKLE LLKKAYEASL SEIKKGHEIE
  1081  KKSLEDLLSE KQESLEKQIN DLKSENDALN EKLKSEEQKR RAREKANLKN PQIMYLEQEL
  1141  ESLKAVLEIK NEKLHQQDIK LMKMEKLVDN NTALVDKLKR FQQENEELKA RMDKHMAISR
  1201  QLSTEQAVLQ ESLEKESKVN KRLSMENEEL LWKLHNGDLC SPKRSPTSSA IPLQSPRNSG
  1261  SFPSPSISPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTUS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 156 nTPM

Expression across tissuesHPA

Tissue

tongue: 156 nTPM
skeletal muscle: 100 nTPM
spinal cord: 95 nTPM
pancreas: 83 nTPM
cerebellum: 80 nTPM
heart muscle: 80 nTPM

Single-cell type

endometrial luminal cells: 815 nCPM
endometrial glandular cells: 744 nCPM
alveolar cells type 2: 718 nCPM
myonuclei: 685 nCPM
pancreatic acinar cells: 639 nCPM
salivary ionocytes: 548 nCPM

Immune cell

naive CD4 T-cell: 1.8 nTPM
naive CD8 T-cell: 1.4 nTPM
memory CD4 T-cell: 0.8 nTPM
total PBMC: 0.4 nTPM
memory CD8 T-cell: 0.2 nTPM
basophil: 0 nTPM

Brain region

white matter: 251 nTPM
medulla oblongata: 170 nTPM
basal ganglia: 152 nTPM
cerebellum: 150 nTPM
pons: 143 nTPM
midbrain: 135 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MTUS1.

Disease | AllUniProt

Conditions MTUS1 is implicated in, by any mechanism.

Hepatocellular carcinoma (HCC) MIM:114550

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: -5.93
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of macrophage chemotaxis

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Microtubule-associated tumor suppressor/Coiled-coil domain-containing protein 69

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTUS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTUS1 as an antibody target. Whether an autoantibody or antibody against MTUS1 could matter depends on whether native MTUS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTUS1 is annotated at the cell surface, where native MTUS1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MTUS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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