AGTR2

Protein identityUniProt · HPA

UniProt accession

P50052

Gene

AGTR2

Ensembl

ENSG00000180772

Chromosome

X

Canonical length

363 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

363 residues, UniProt reviewed canonical sequence.

>P50052|AGTR2
     1  MKGNSTLATT SKNITSGLHF GLVNISGNNE STLNCSQKPS DKHLDAIPIL YYIIFVIGFL
    61  VNIVVVTLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF
   121  GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYIVPLVWCM ACLSSLPTFY
   181  FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK
   241  TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LAWMGVINSC EVIAVIDLAL
   301  PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRESMSCR KSSSLREMET
   361  FVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGTR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0.01

gnomAD missense Z

-0.07

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
• blood vessel remodeling
• brain development
• brain renin-angiotensin system
• cell surface receptor signaling pathway
• exploration behavior
• G protein-coupled receptor signaling pathway
• G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
• inflammatory response
• negative regulation of blood vessel endothelial cell migration
• negative regulation of cell growth
• negative regulation of heart rate
• negative regulation of neurotrophin TRK receptor signaling pathway
• neuron apoptotic process
• nitric oxide-cGMP-mediated signaling
• positive regulation of branching involved in ureteric bud morphogenesis
• positive regulation of DNA-templated transcription
• positive regulation of extrinsic apoptotic signaling pathway
• positive regulation of metanephric glomerulus development
• regulation of blood pressure
• regulation of metanephros size
• vasodilation
• regulation of systemic arterial blood pressure by circulatory renin-angiotensin

Molecular functions

• angiotensin type II receptor activity
• receptor antagonist activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Angiotensin II receptor family
• G protein-coupled receptor, rhodopsin-like
• GPCR, rhodopsin-like, 7TM
• C-C chemokine receptor type 1-9-like
• 7 transmembrane receptor (rhodopsin family)
• Angiotensin II receptor type 2

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of AGTR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MTUS1
• TIMP3