Seroatlas · Human Serome Atlas

MTMR11

Myotubularin-related protein 11

Also known as: CRA, MTMRB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4FU01
Gene: MTMR11
Ensembl: ENSG00000014914
Chromosome: 1
Canonical length: 709 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome

OverviewNCBI Gene

Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

709 residues, UniProt reviewed canonical sequence.

>A4FU01|MTMR11
     1  MWWGGRGQSF NIAPQKEEPE MGSVQENRMP EPRSRQPSSC LASRCLPGEQ ILAWAPGVRK
    61  GLEPELSGTL ICTNFRVTFQ PCGWQWNQDT PLNSEYDFAL VNIGRLEAVS GLSRVQLLRP
   121  GSLHKFIPEE ILIHGRDFRL LRVGFEAGGL EPQAFQVTMA IVQARAQSNQ AQQYSGITLS
   181  KAGQGSGSRK PPIPLMETAE DWETERKKQA ARGWRVSTVN ERFDVATSLP RYFWVPNRIL
   241  DSEVRRAFGH FHQGRGPRLS WHHPGGSDLL RCGGFYTASD PNKEDIRAVE LMLQAGHSDV
   301  VLVDTMDELP SLADVQLAHL RLRALCLPDS SVAEDKWLSA LEGTRWLDYV RACLRKASDI
   361  SVLVTSRVRS VILQERGDRD LNGLLSSLVQ LLSAPEARTL FGFQSLVQRE WVAAGHPFLT
   421  RLGGTGASEE APVFLLFLDC VWQLLQQFPA DFEFSEFFLL ALHDSVRVPD TLTFLRNTPW
   481  ERGKQSGQLN SYTQVYTPGY SQPPAGNSFN LQLSVWDWDL RYSNAQILQF QNPGYDPEHC
   541  PDSWLPRPQP SFMVPGPPSS VWLFSRGALT PLNQLCPWRD SPSLLAVSSR WLPRPAISSE
   601  SLADQEWGLP SHWGACPLPP GLLLPGYLGP QIRLWRRCYL RGRPEVQMGL SAPTISGLQD
   661  ELSHLQELLR KWTPRISPED HSKKRDPHTI LNPTEIAGIL KGRAEGDLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTMR11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

rectum: 25 nTPM
small intestine: 22 nTPM
colon: 21 nTPM
duodenum: 19 nTPM
blood vessel: 18 nTPM
ovary: 14 nTPM

Single-cell type

enterocytes: 129 nCPM
colonocytes: 118 nCPM
goblet cells: 106 nCPM
enteric stem cells: 51 nCPM
gastric progenitor cells: 50 nCPM
enteric transient amplifying cells: 47 nCPM

Immune cell

myeloid DC: 1.7 nTPM
intermediate monocyte: 1.3 nTPM
non-classical monocyte: 1.3 nTPM
classical monocyte: 0.8 nTPM
total PBMC: 0.3 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 12 nTPM
medulla oblongata: 7.3 nTPM
midbrain: 6 nTPM
spinal cord: 6 nTPM
white matter: 5.6 nTPM
hypothalamus: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.98
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTMR11 as an antibody target. Whether an autoantibody or antibody against MTMR11 could matter depends on whether native MTMR11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTMR11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTMR11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...