Seroatlas · Human Serome Atlas

MTMR10

Myotubularin-related protein 10

Also known as: FLJ20313, MTMRA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXD2
Gene: MTMR10
Ensembl: ENSG00000166912
Chromosome: 15
Canonical length: 777 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

777 residues, UniProt reviewed canonical sequence.

>Q9NXD2|MTMR10
     1  MFSLKPPKPT FRSYLLPPPQ TDDKINSEPK IKKLEPVLLP GEIVVNEVNF VRKCIATDTS
    61  QYDLWGKLIC SNFKISFITD DPMPLQKFHY RNLLLGEHDV PLTCIEQIVT VNDHKRKQKV
   121  LGPNQKLKFN PTELIIYCKD FRIVRFRFDE SGPESAKKVC LAIAHYSQPT DLQLLFAFEY
   181  VGKKYHNSAN KINGIPSGDG GGGGGGGNGA GGGSSQKTPL FETYSDWDRE IKRTGASGWR
   241  VCSINEGYMI STCLPEYIVV PSSLADQDLK IFSHSFVGRR MPLWCWSHSN GSALVRMALI
   301  KDVLQQRKID QRICNAITKS HPQRSDVYKS DLDKTLPNIQ EVQAAFVKLK QLCVNEPFEE
   361  TEEKWLSSLE NTRWLEYVRA FLKHSAELVY MLESKHLSVV LQEEEGRDLS CCVASLVQVM
   421  LDPYFRTITG FQSLIQKEWV MAGYQFLDRC NHLKRSEKES PLFLLFLDAT WQLLEQYPAA
   481  FEFSETYLAV LYDSTRISLF GTFLFNSPHQ RVKQSTEFAI SKNIQLGDEK GLKFPSVWDW
   541  SLQFTAKDRT LFHNPFYIGK STPCIQNGSV KSFKRTKKSY SSTLRGMPSA LKNGIISDQE
   601  LLPRRNSLIL KPKPDPAQQT DSQNSDTEQY FREWFSKPAN LHGVILPRVS GTHIKLWKLC
   661  YFRWVPEAQI SLGGSITAFH KLSLLADEVD VLSRMLRQQR SGPLEACYGE LGQSRMYFNA
   721  SGPHHTDTSG TPEFLSSSFP FSPVGNLCRR SILGTPLSKF LSGAKIWLST ETLANED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTMR10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 78 nTPM
kidney: 29 nTPM
skeletal muscle: 28 nTPM
midbrain: 26 nTPM
placenta: 24 nTPM
liver: 23 nTPM

Single-cell type

renal connecting tubule cells: 224 nCPM
renal collecting duct principal cells: 177 nCPM
oligodendrocytes: 159 nCPM
distal convoluted tubule cells: 143 nCPM
loop of henle epithelial cells: 131 nCPM
renal collecting duct intercalated cells: 116 nCPM

Immune cell

neutrophil: 14 nTPM
non-classical monocyte: 7.4 nTPM
intermediate monocyte: 4 nTPM
basophil: 3.8 nTPM
plasmacytoid DC: 3.7 nTPM
classical monocyte: 3.2 nTPM

Brain region

white matter: 109 nTPM
medulla oblongata: 100 nTPM
cerebellum: 82 nTPM
midbrain: 79 nTPM
basal ganglia: 75 nTPM
spinal cord: 74 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 1.27
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Myotubularin-like, phosphatase domain
PH-like domain superfamily
Myotubularin-related 12-like C-terminal domain
Protein-tyrosine phosphatase-like
Myotubularin
Myotubularin-like phosphatase domain
Myotubularin-associated protein
Myotubularin-related protein 10, protein tyrosine phosphatase domain
MTMR10, PH-GRAM domain

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTMR10 as an antibody target. Whether an autoantibody or antibody against MTMR10 could matter depends on whether native MTMR10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTMR10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTMR10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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