Seroatlas · Human Serome Atlas

MTLN

Mitoregulin

Also known as: LEMP, LINC00116, MOXI, MPM, MTLN_HUMAN, NCRNA00116, SMIM37

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NCU8
Gene
MTLN
Ensembl
ENSG00000175701
Chromosome
2
Canonical length
56 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Involved in several processes, including positive regulation of mitochondrial membrane potential; positive regulation of sequestering of calcium ion; and triglyceride homeostasis. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

56 residues, UniProt reviewed canonical sequence.

>Q8NCU8|MTLN
     1  MADVSERTLQ LSVLVAFASG VLLGWQANRL RRRYLDWRKR RLQDKLAATQ KKLDLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
736 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 736 nTPM
  • tongue: 262 nTPM
  • heart muscle: 233 nTPM
  • midbrain: 90 nTPM
  • cerebral cortex: 85 nTPM
  • amygdala: 81 nTPM

Single-cell type

  • parietal cells: 285 nCPM
  • hepatocytes: 271 nCPM
  • megakaryocytes: 210 nCPM
  • esophageal suprabasal cells: 180 nCPM
  • endometrial luminal cells: 160 nCPM
  • enterocytes: 150 nCPM

Immune cell

  • plasmacytoid DC: 151 nTPM
  • naive CD8 T-cell: 130 nTPM
  • naive CD4 T-cell: 130 nTPM
  • MAIT T-cell: 126 nTPM
  • memory CD4 T-cell: 124 nTPM
  • T-reg: 119 nTPM

Brain region

  • cerebellum: 84 nTPM
  • cerebral cortex: 80 nTPM
  • thalamus: 78 nTPM
  • hypothalamus: 77 nTPM
  • pons: 73 nTPM
  • white matter: 71 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Mitoregulin
  • Mitoregulin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTLN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTLN as an antibody target. Whether an autoantibody or antibody against MTLN could matter depends on whether native MTLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTLN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MTLN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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