Seroatlas · Human Serome Atlas

MTCH1

Mitochondrial carrier homolog 1

Also known as: CGI-64, MTCH1_HUMAN, PSAP, SLC25A49

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZJ7
Gene
MTCH1
Ensembl
ENSG00000137409
Chromosome
6
Canonical length
389 aa
Protein class
Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q9NZJ7|MTCH1
     1  MGASDPEVAP WARGGAAGMA GAGAGAGARG GAAAGVEARA RDPPPAHRAH PRHPRPAAQP
    61  SARRMDGGSG GLGSGDNAPT TEALFVALGA GVTALSHPLL YVKLLIQVGH EPMPPTLGTN
   121  VLGRKVLYLP SFFTYAKYIV QVDGKIGLFR GLSPRLMSNA LSTVTRGSMK KVFPPDEIEQ
   181  VSNKDDMKTS LKKVVKETSY EMMMQCVSRM LAHPLHVISM RCMVQFVGRE AKYSGVLSSI
   241  GKIFKEEGLL GFFVGLIPHL LGDVVFLWGC NLLAHFINAY LVDDSVSDTP GGLGNDQNPG
   301  SQFSQALAIR SYTKFVMGIA VSMLTYPFLL VGDLMAVNNC GLQAGLPPYS PVFKSWIHCW
   361  KYLSVQGQLF RGSSLLFRRV SSGSCFALE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTCH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
354 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 354 nTPM
  • cerebral cortex: 312 nTPM
  • basal ganglia: 283 nTPM
  • pituitary gland: 281 nTPM
  • hypothalamus: 280 nTPM
  • adrenal gland: 275 nTPM

Single-cell type

  • epididymal principal cells: 800 nCPM
  • epididymal efferent duct absorptive cells: 425 nCPM
  • decidual stromal cells: 335 nCPM
  • breast lactating cells: 314 nCPM
  • esophageal apical cells: 300 nCPM
  • syncytiotrophoblasts: 285 nCPM

Immune cell

  • eosinophil: 45 nTPM
  • non-classical monocyte: 45 nTPM
  • neutrophil: 36 nTPM
  • intermediate monocyte: 35 nTPM
  • classical monocyte: 35 nTPM
  • naive B-cell: 31 nTPM

Brain region

  • hypothalamus: 351 nTPM
  • pons: 331 nTPM
  • basal ganglia: 322 nTPM
  • cerebral cortex: 315 nTPM
  • thalamus: 294 nTPM
  • white matter: 292 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.65
gnomAD missense Z
2.45
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTCH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTCH1 as an antibody target. Whether an autoantibody or antibody against MTCH1 could matter depends on whether native MTCH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTCH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTCH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MTCH1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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