Seroatlas · Human Serome Atlas

MSANTD4

Myb/SANT-like DNA-binding domain-containing protein 4

Also known as: KIAA1826, MSD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCY6
Gene: MSANTD4
Ensembl: ENSG00000170903
Chromosome: 11
Canonical length: 345 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q8NCY6|MSANTD4
     1  MKQLKRKRKS NFSVQETQTL LKEITKRKEV IFSKQLNTTI NVMKRMAWEE IAQCVNAVGE
    61  GEQRTGTEVK RRYLDWRALM KRKRMKANIK LVGSGFPLPS SDLDDSLTEE IDEKIGFRND
   121  ANFDWQNVAD FRDAGGSLTE VKVEEEERDP QSPEFEIEEE EEMLSSVIPD SRRENELPDF
   181  PHIDEFFTLN STPSRSAYDE PHLLVNIEKQ KLELEKRRLD IEAERLQVEK ERLQIEKERL
   241  RHLDMEHERL QLEKERLQIE REKLRLQIVN SEKPSLENEL GQGEKSMLQP QDIETEKLKL
   301  ERERLQLEKD RLQFLKFESE KLQIEKERLQ VEKDRLRIQK EGHLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSANTD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

retina: 31 nTPM
tongue: 16 nTPM
cerebral cortex: 15 nTPM
heart muscle: 15 nTPM
thyroid gland: 12 nTPM
seminal vesicle: 11 nTPM

Single-cell type

müller glia: 150 nCPM
bergmann glia: 71 nCPM
corticotrophs: 50 nCPM
oligodendrocyte progenitor cells: 50 nCPM
oligodendrocytes: 45 nCPM
astrocytes: 43 nCPM

Immune cell

naive CD4 T-cell: 8.1 nTPM
NK-cell: 8.1 nTPM
gdT-cell: 8 nTPM
MAIT T-cell: 7.9 nTPM
intermediate monocyte: 7.8 nTPM
naive CD8 T-cell: 7.2 nTPM

Brain region

cerebral cortex: 40 nTPM
cerebellum: 40 nTPM
white matter: 38 nTPM
basal ganglia: 36 nTPM
thalamus: 35 nTPM
medulla oblongata: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.01
gnomAD missense Z: 0.86
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Myb/SANT-like DNA-binding domain 5
Myb/SANT-like DNA-binding domain
Myb/SANT-like DNA-binding domain-containing protein 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MSANTD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RALBP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSANTD4 as an antibody target. Whether an autoantibody or antibody against MSANTD4 could matter depends on whether native MSANTD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSANTD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSANTD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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