Seroatlas · Human Serome Atlas

MRPL43

Large ribosomal subunit protein mL43

Also known as: bMRP36a, RM43_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N983
Gene
MRPL43
Ensembl
ENSG00000055950
Chromosome
10
Canonical length
215 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene and the gene for a semaphorin class 4 protein (SEMA4G) overlap at map location 10q24.31 and are transcribed in opposite directions. Sequence analysis identified multiple transcript variants encoding at least four different protein isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>Q8N983|MRPL43
     1  MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE VIDFARRNPG
    61  VVIYVNSRPC CVPRVVAEYL NGAVREESIH CKSVEEISTL VQKLADQSGL DVIRIRKPFH
   121  TDNPSIQGQW HPFTNKPTTF RGLRPREVQD PAPAQDTGLR LSAVAPQILL PGWPDPPDLP
   181  TVDPISSSLT SAPAPMLSAV SCLPIVPALT TVCSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
112 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 112 nTPM
  • kidney: 92 nTPM
  • spinal cord: 85 nTPM
  • adrenal gland: 83 nTPM
  • liver: 81 nTPM
  • pancreas: 74 nTPM

Single-cell type

  • late primary spermatocytes: 485 nCPM
  • esophageal suprabasal cells: 200 nCPM
  • extravillous trophoblasts: 177 nCPM
  • esophageal basal cells: 168 nCPM
  • epididymal principal cells: 159 nCPM
  • cytotrophoblasts: 156 nCPM

Immune cell

  • basophil: 101 nTPM
  • T-reg: 77 nTPM
  • NK-cell: 73 nTPM
  • eosinophil: 71 nTPM
  • myeloid DC: 69 nTPM
  • total PBMC: 68 nTPM

Brain region

  • cerebellum: 53 nTPM
  • white matter: 53 nTPM
  • medulla oblongata: 46 nTPM
  • pons: 46 nTPM
  • basal ganglia: 46 nTPM
  • spinal cord: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0
gnomAD missense Z
1.09
DepMap mean gene effect
-0.58
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL43 as an antibody target. Whether an autoantibody or antibody against MRPL43 could matter depends on whether native MRPL43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPL43. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...