MOXD1

Protein identityUniProt · HPA

UniProt accession

Q6UVY6

Gene

MOXD1

Ensembl

ENSG00000079931

Chromosome

6

Canonical length

613 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Cytosol

OverviewNCBI Gene

Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Part of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

613 residues, UniProt reviewed canonical sequence.

>Q6UVY6|MOXD1
     1  MCCWPLLLLW GLLPGTAAGG SGRTYPHRTL LDSEGKYWLG WSQRGSQIAF RLQVRTAGYV
    61  GFGFSPTGAM ASADIVVGGV AHGRPYLQDY FTNANRELKK DAQQDYHLEY AMENSTHTII
   121  EFTRELHTCD INDKSITDST VRVIWAYHHE DAGEAGPKYH DSNRGTKSLR LLNPEKTSVL
   181  STALPYFDLV NQDVPIPNKD TTYWCQMFKI PVFQEKHHVI KVEPVIQRGH ESLVHHILLY
   241  QCSNNFNDSV LESGHECYHP NMPDAFLTCE TVIFAWAIGG EGFSYPPHVG LSLGTPLDPH
   301  YVLLEVHYDN PTYEEGLIDN SGLRLFYTMD IRKYDAGVIE AGLWVSLFHT IPPGMPEFQS
   361  EGHCTLECLE EALEAEKPSG IHVFAVLLHA HLAGRGIRLR HFRKGKEMKL LAYDDDFDFN
   421  FQEFQYLKEE QTILPGDNLI TECRYNTKDR AEMTWGGLST RSEMCLSYLL YYPRINLTRC
   481  ASIPDIMEQL QFIGVKEIYR PVTTWPFIIK SPKQYKNLSF MDAMNKFKWT KKEGLSFNKL
   541  VLSLPVNVRC SKTDNAEWSI QGMTALPPDI ERPYKAEPLV CGTSSSSSLH RDFSINLLVC
   601  LLLLSCTLST KSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOXD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

74 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.45

gnomAD pLI

0

gnomAD missense Z

-0.54

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• dopamine catabolic process
• norepinephrine biosynthetic process
• octopamine biosynthetic process

Molecular functions

• copper ion binding
• dopamine beta-monooxygenase activity

Cellular components

• endoplasmic reticulum membrane
• extracellular space
• secretory granule membrane

Protein domainsUniProt · Pfam · InterPro

• Copper type II, ascorbate-dependent monooxygenase, N-terminal
• Dopamine beta-hydroxylase-like
• DOMON domain
• PHM/PNGase F domain superfamily
• Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
• Copper type II ascorbate-dependent monooxygenase, C-terminal
• Tyramine beta-hydroxylase/Dopamine beta-hydroxylase
• Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
• Copper-dependent monooxygenases, DOMON domain
• Copper type II ascorbate-dependent monooxygenase, N-terminal domain
• DOMON domain
• Copper type II ascorbate-dependent monooxygenase, C-terminal domain

KeywordsUniProt

• Copper
• Disulfide bond
• Endoplasmic reticulum
• Glycoprotein
• Membrane
• Metal-binding
• Monooxygenase
• Oxidoreductase
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MOXD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GLRX3