Seroatlas · Human Serome Atlas

MOCS3

Adenylyltransferase and sulfurtransferase MOCS3

Also known as: dJ914P20.3, MOCS3_HUMAN, UBA4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95396
Gene
MOCS3
Ensembl
ENSG00000124217
Chromosome
20
Canonical length
460 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

460 residues, UniProt reviewed canonical sequence.

>O95396|MOCS3
     1  MASREEVLAL QAEVAQREEE LNSLKQKLAS ALLAEQEPQP ERLVPVSPLP PKAALSRDEI
    61  LRYSRQLVLP ELGVHGQLRL GTACVLIVGC GGLGCPLAQY LAAAGVGRLG LVDYDVVEMS
   121  NLARQVLHGE ALAGQAKAFS AAASLRRLNS AVECVPYTQA LTPATALDLV RRYDVVADCS
   181  DNVPTRYLVN DACVLAGRPL VSASALRFEG QITVYHYDGG PCYRCIFPQP PPAETVTNCA
   241  DGGVLGVVTG VLGCLQALEV LKIAAGLGPS YSGSLLLFDA LRGHFRSIRL RSRRLDCAAC
   301  GERPTVTDLL DYEAFCGSSA TDKCRSLQLL SPEERVSVTD YKRLLDSGAF HLLLDVRPQV
   361  EVDICRLPHA LHIPLKHLER RDAESLKLLK EAIWEEKQGT QEGAAVPIYV ICKLGNDSQK
   421  AVKILQSLSA AQELDPLTVR DVVGGLMAWA AKIDGTFPQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOCS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
4.6 nTPM

Expression across tissuesHPA

Tissue

  • testis: 4.6 nTPM
  • epididymis: 2.5 nTPM
  • fallopian tube: 2.4 nTPM
  • liver: 2.3 nTPM
  • lymph node: 2.3 nTPM
  • skeletal muscle: 2.3 nTPM

Single-cell type

  • early spermatids: 122 nCPM
  • late spermatids: 32 nCPM
  • late primary spermatocytes: 26 nCPM
  • tuft cells: 23 nCPM
  • parietal cells: 18 nCPM
  • early primary spermatocytes: 15 nCPM

Immune cell

  • non-classical monocyte: 5.8 nTPM
  • T-reg: 5.6 nTPM
  • naive CD4 T-cell: 5.5 nTPM
  • memory B-cell: 4.6 nTPM
  • myeloid DC: 4.5 nTPM
  • NK-cell: 4.4 nTPM

Brain region

  • hypothalamus: 5.7 nTPM
  • cerebral cortex: 5.6 nTPM
  • cerebellum: 5.5 nTPM
  • choroid plexus: 5.5 nTPM
  • basal ganglia: 5.4 nTPM
  • hippocampal formation: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.36
gnomAD pLI
0
gnomAD missense Z
0.67
DepMap mean gene effect
-0.7
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MOCS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOCS3 as an antibody target. Whether an autoantibody or antibody against MOCS3 could matter depends on whether native MOCS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOCS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOCS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MOCS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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