Seroatlas · Human Serome Atlas

MOCS1

Molybdenum cofactor biosynthesis protein 1

Also known as: MOCOD, MOCS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZB8
Gene
MOCS1
Ensembl
ENSG00000124615
Chromosome
6
Canonical length
636 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. [provided by RefSeq, Nov 2017]

Canonical amino-acid sequenceUniProt

636 residues, UniProt reviewed canonical sequence.

>Q9NZB8|MOCS1
     1  MAARPLSRML RRLLRSSARS CSSGAPVTQP CPGESARAAS EEVSRRRQFL REHAAPFSAF
    61  LTDSFGRQHS YLRISLTEKC NLRCQYCMPE EGVPLTPKAN LLTTEEILTL ARLFVKEGID
   121  KIRLTGGEPL IRPDVVDIVA QLQRLEGLRT IGVTTNGINL ARLLPQLQKA GLSAINISLD
   181  TLVPAKFEFI VRRKGFHKVM EGIHKAIELG YNPVKVNCVV MRGLNEDELL DFAALTEGLP
   241  LDVRFIEYMP FDGNKWNFKK MVSYKEMLDT VRQQWPELEK VPEEESSTAK AFKIPGFQGQ
   301  ISFITSMSEH FCGTCNRLRI TADGNLKVCL FGNSEVSLRD HLRAGASEQE LLRIIGAAVG
   361  RKKRQHAGMF SISQMKNRPM ILIELFLMFP NSPPANPSIF SWDPLHVQGL RPRMSFSSQV
   421  ATLWKGCRVP QTPPLAQQRL GSGSFQRHYT SRADSDANSK CLSPGSWASA APSGPQLTSE
   481  QLTHVDSEGR AAMVDVGRKP DTERVAVASA VVLLGPVAFK LVQQNQLKKG DALVVAQLAG
   541  VQAAKVTSQL IPLCHHVALS HIQVQLELDS TRHAVKIQAS CRARGPTGVE MEALTSAAVA
   601  ALTLYDMCKA VSRDIVLEEI KLISKTGGQR GDFHRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOCS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • liver: 42 nTPM
  • tongue: 42 nTPM
  • adipose tissue: 41 nTPM
  • breast: 35 nTPM
  • placenta: 33 nTPM
  • blood vessel: 31 nTPM

Single-cell type

  • pericytes: 93 nCPM
  • adipocytes: 92 nCPM
  • hepatocytes: 49 nCPM
  • cytotrophoblasts: 46 nCPM
  • epicardial cells: 43 nCPM
  • vascular smooth muscle cells: 38 nCPM

Immune cell

  • naive CD4 T-cell: 0.6 nTPM
  • naive CD8 T-cell: 0.5 nTPM
  • NK-cell: 0.4 nTPM
  • gdT-cell: 0.3 nTPM
  • total PBMC: 0.2 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • midbrain: 26 nTPM
  • basal ganglia: 24 nTPM
  • thalamus: 24 nTPM
  • medulla oblongata: 23 nTPM
  • cerebellum: 22 nTPM
  • white matter: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MOCS1.

Disease | AllUniProt

Conditions MOCS1 is implicated in, by any mechanism.

  • Molybdenum cofactor deficiency A (MOCODA) MIM:252150

Disease | GeneticClinVar

89 pathogenic / likely-pathogenic of 815 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
-0.62
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOCS1 as an antibody target. Whether an autoantibody or antibody against MOCS1 could matter depends on whether native MOCS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOCS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOCS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MOCS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...