Seroatlas · Human Serome Atlas

MMP28

Matrix metalloproteinase-28

Also known as: EPILYSIN, MM28, MMP-25, MMP-28, MMP28_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H239
Gene: MMP28
Ensembl: ENSG00000271447
Chromosome: 17
Canonical length: 520 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q9H239|MMP28
     1  MVARVGLLLR ALQLLLWGHL DAQPAERGGQ ELRKEAEAFL EKYGYLNEQV PKAPTSTRFS
    61  DAIRAFQWVS QLPVSGVLDR ATLRQMTRPR CGVTDTNSYA AWAERISDLF ARHRTKMRRK
   121  KRFAKQGNKW YKQHLSYRLV NWPEHLPEPA VRGAVRAAFQ LWSNVSALEF WEAPATGPAD
   181  IRLTFFQGDH NDGLGNAFDG PGGALAHAFL PRRGEAHFDQ DERWSLSRRR GRNLFVVLAH
   241  EIGHTLGLTH SPAPRALMAP YYKRLGRDAL LSWDDVLAVQ SLYGKPLGGS VAVQLPGKLF
   301  TDFETWDSYS PQGRRPETQG PKYCHSSFDA ITVDRQQQLY IFKGSHFWEV AADGNVSEPR
   361  PLQERWVGLP PNIEAAAVSL NDGDFYFFKG GRCWRFRGPK PVWGLPQLCR AGGLPRHPDA
   421  ALFFPPLRRL ILFKGARYYV LARGGLQVEP YYPRSLQDWG GIPEEVSGAL PRPDGSIIFF
   481  RDDRYWRLDQ AKLQATTSGR WATELPWMGC WHANSGSALF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMP28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

skin: 29 nTPM
testis: 28 nTPM
basal ganglia: 22 nTPM
amygdala: 21 nTPM
colon: 20 nTPM
urinary bladder: 19 nTPM

Single-cell type

astrocytes: 100 nCPM
papillary tip epithelial cells: 79 nCPM
late spermatids: 55 nCPM
podocytes: 50 nCPM
renal collecting duct principal cells: 34 nCPM
early spermatids: 33 nCPM

Immune cell

naive CD4 T-cell: 6.3 nTPM
naive CD8 T-cell: 3.8 nTPM
MAIT T-cell: 1.1 nTPM
memory CD8 T-cell: 1 nTPM
NK-cell: 0.9 nTPM
plasmacytoid DC: 0.9 nTPM

Brain region

thalamus: 23 nTPM
amygdala: 22 nTPM
basal ganglia: 20 nTPM
midbrain: 20 nTPM
cerebral cortex: 16 nTPM
hippocampal formation: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMP28 as an antibody target. Whether an autoantibody or antibody against MMP28 could matter depends on whether native MMP28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMP28 is annotated as secreted, so native MMP28 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MMP28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...