Seroatlas · Human Serome Atlas

MMP25

Matrix metalloproteinase-25

Also known as: MMP20, MMP25_HUMAN, MMPL1, MT6-MMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPA2
Gene: MMP25
Ensembl: ENSG00000008516
Chromosome: 16
Canonical length: 562 aa
Protein class: Enzymes, Predicted secreted proteins
Subcellular location: Plasma membrane
Secretome location: Secreted to blood

OverviewNCBI Gene

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

562 residues, UniProt reviewed canonical sequence.

>Q9NPA2|MMP25
     1  MRLRLRLLAL LLLLLAPPAR APKPSAQDVS LGVDWLTRYG YLPPPHPAQA QLQSPEKLRD
    61  AIKVMQRFAG LPETGRMDPG TVATMRKPRC SLPDVLGVAG LVRRRRRYAL SGSVWKKRTL
   121  TWRVRSFPQS SQLSQETVRV LMSYALMAWG MESGLTFHEV DSPQGQEPDI LIDFARAFHQ
   181  DSYPFDGLGG TLAHAFFPGE HPISGDTHFD DEETWTFGSK DGEGTDLFAV AVHEFGHALG
   241  LGHSSAPNSI MRPFYQGPVG DPDKYRLSQD DRDGLQQLYG KAPQTPYDKP TRKPLAPPPQ
   301  PPASPTHSPS FPIPDRCEGN FDAIANIRGE TFFFKGPWFW RLQPSGQLVS PRPARLHRFW
   361  EGLPAQVRVV QAAYARHRDG RILLFSGPQF WVFQDRQLEG GARPLTELGL PPGEEVDAVF
   421  SWPQNGKTYL VRGRQYWRYD EAAARPDPGY PRDLSLWEGA PPSPDDVTVS NAGDTYFFKG
   481  AHYWRFPKNS IKTEPDAPQP MGPNWLDCPA PSSGPRAPRP PKATPVSETC DCQCELNQAA
   541  GRWPAPIPLL LLPLLVGGVA SR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMP25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

spleen: 75 nTPM
bone marrow: 31 nTPM
appendix: 14 nTPM
lung: 13 nTPM
adipose tissue: 5.2 nTPM
tongue: 3.2 nTPM

Single-cell type

neutrophils: 577 nCPM
cardiomyocytes: 72 nCPM
neutrophil progenitors: 65 nCPM
epicardial cells: 36 nCPM
innate lymphoid cells: 32 nCPM
endometrial secretory cells: 29 nCPM

Immune cell

neutrophil: 20 nTPM
basophil: 18 nTPM
eosinophil: 4 nTPM
NK-cell: 0.5 nTPM
plasmacytoid DC: 0.4 nTPM
classical monocyte: 0.2 nTPM

Brain region

cerebral cortex: 3.4 nTPM
thalamus: 1.4 nTPM
medulla oblongata: 1.2 nTPM
pons: 1.2 nTPM
choroid plexus: 1.1 nTPM
amygdala: 1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MMP25.

Disease | ImmuneIEDB

Conditions an epitope on MMP25 was assayed in.

multiple sclerosis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -0.88
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMP25 as an antibody target. Whether an autoantibody or antibody against MMP25 could matter depends on whether native MMP25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMP25 is annotated at the cell surface, where native MMP25 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MMP25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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