Seroatlas · Human Serome Atlas

MMP23B

Matrix metalloproteinase-23

Also known as: MIFR, MIFR-1, MMP22, MMP23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75900
Gene: MMP23B
Ensembl: ENSG00000189409
Chromosome: 1
Canonical length: 390 aa
Protein class: Enzymes, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>O75900|MMP23B
     1  MGRGARVPSE APGAGVERRW LGAALVALCL LPALVLLARL GAPAVPAWSA AQGDVAALGL
    61  SAVPPTRVPG PLAPRRRRYT LTPARLRWDH FNLTYRILSF PRNLLSPRET RRALAAAFRM
   121  WSDVSPFSFR EVAPEQPSDL RIGFYPINHT DCLVSALHHC FDGPTGELAH AFFPPHGGIH
   181  FDDSEYWVLG PTRYSWKKGV WLTDLVHVAA HEIGHALGLM HSQHGRALMH LNATLRGWKA
   241  LSQDELWGLH RLYGCLDRLF VCASWARRGF CDARRRLMKR LCPSSCDFCY EFPFPTVATT
   301  PPPPRTKTRL VPEGRNVTFR CGQKILHKKG KVYWYKDQEP LEFSYPGYLA LGEAHLSIIA
   361  NAVNEGTYTC VVRRQQRVLT TYSWRVRVRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMP23B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

ovary: 26 nTPM
blood vessel: 21 nTPM
heart muscle: 14 nTPM
endometrium: 13 nTPM
lung: 13 nTPM
prostate: 11 nTPM

Single-cell type

peritubular myoid cells: 15 nCPM
leydig cells: 15 nCPM
ovarian stromal cells: 9.5 nCPM
corticotrophs: 7.6 nCPM
hepatic stellate cells: 6.5 nCPM
oocytes: 4.6 nCPM

Immune cell

plasmacytoid DC: 11 nTPM
NK-cell: 2.2 nTPM
total PBMC: 1.7 nTPM
gdT-cell: 1.5 nTPM
memory CD8 T-cell: 1 nTPM
MAIT T-cell: 0.9 nTPM

Brain region

cerebral cortex: 3.4 nTPM
basal ganglia: 3.3 nTPM
amygdala: 3.2 nTPM
medulla oblongata: 3 nTPM
cerebellum: 2.6 nTPM
hippocampal formation: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0.12
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMP23B as an antibody target. Whether an autoantibody or antibody against MMP23B could matter depends on whether native MMP23B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMP23B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MMP23B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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