Seroatlas · Human Serome Atlas

MMP19

Matrix metalloproteinase-19

Also known as: MMP18, MMP19_HUMAN, RASI-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99542
Gene
MMP19
Ensembl
ENSG00000123342
Chromosome
12
Canonical length
508 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted secreted proteins
Subcellular location
Endoplasmic reticulum,Vesicles
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q99542|MMP19
     1  MNCQQLWLGF LLPMTVSGRV LGLAEVAPVD YLSQYGYLQK PLEGSNNFKP EDITEALRAF
    61  QEASELPVSG QLDDATRARM RQPRCGLEDP FNQKTLKYLL LGRWRKKHLT FRILNLPSTL
   121  PPHTARAALR QAFQDWSNVA PLTFQEVQAG AADIRLSFHG RQSSYCSNTF DGPGRVLAHA
   181  DIPELGSVHF DEDEFWTEGT YRGVNLRIIA AHEVGHALGL GHSRYSQALM APVYEGYRPH
   241  FKLHPDDVAG IQALYGKKSP VIRDEEEEET ELPTVPPVPT EPSPMPDPCS SELDAMMLGP
   301  RGKTYAFKGD YVWTVSDSGP GPLFRVSALW EGLPGNLDAA VYSPRTQWIH FFKGDKVWRY
   361  INFKMSPGFP KKLNRVEPNL DAALYWPLNQ KVFLFKGSGY WQWDELARTD FSSYPKPIKG
   421  LFTGVPNQPS AAMSWQDGRV YFFKGKVYWR LNQQLRVEKG YPRNISHNWM HCRPRTIDTT
   481  PSGGNTTPSG TGITLDTTLS ATETTFEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMP19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 38 nTPM
  • gallbladder: 24 nTPM
  • spleen: 18 nTPM
  • lung: 16 nTPM
  • blood vessel: 15 nTPM
  • breast: 12 nTPM

Single-cell type

  • monocytes: 272 nCPM
  • macrophages: 238 nCPM
  • kupffer cells: 132 nCPM
  • ovarian stromal cells: 131 nCPM
  • hepatic stellate cells: 129 nCPM
  • decidual stromal cells: 122 nCPM

Immune cell

  • classical monocyte: 0.5 nTPM
  • myeloid DC: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • thalamus: 2.7 nTPM
  • choroid plexus: 0.9 nTPM
  • cerebral cortex: 0.4 nTPM
  • pons: 0.4 nTPM
  • basal ganglia: 0.3 nTPM
  • hippocampal formation: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MMP19.

Disease | AllUniProt

Conditions MMP19 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 99 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Familial cavitary optic disk anomaly

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.47
gnomAD pLI
0
gnomAD missense Z
0.36
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMP19 as an antibody target. Whether an autoantibody or antibody against MMP19 could matter depends on whether native MMP19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMP19 is annotated as secreted, so native MMP19 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MMP19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MMP19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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