Seroatlas · Human Serome Atlas

MMP17

Matrix metalloproteinase-17

Also known as: MMP17_HUMAN, MT4-MMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULZ9
Gene
MMP17
Ensembl
ENSG00000198598
Chromosome
12
Canonical length
603 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

603 residues, UniProt reviewed canonical sequence.

>Q9ULZ9|MMP17
     1  MRRRAARGPG PPPPGPGLSR LPLPLLLLLA LGTRGGCAAP APAPRAEDLS LGVEWLSRFG
    61  YLPPADPTTG QLQTQEELSK AITAMQQFGG LEATGILDEA TLALMKTPRC SLPDLPVLTQ
   121  ARRRRQAPAP TKWNKRNLSW RVRTFPRDSP LGHDTVRALM YYALKVWSDI APLNFHEVAG
   181  SAADIQIDFS KADHNDGYPF DGPGGTVAHA FFPGHHHTAG DTHFDDDEAW TFRSSDAHGM
   241  DLFAVAVHEF GHAIGLSHVA AAHSIMRPYY QGPVGDPLRY GLPYEDKVRV WQLYGVRESV
   301  SPTAQPEEPP LLPEPPDNRS SAPPRKDVPH RCSTHFDAVA QIRGEAFFFK GKYFWRLTRD
   361  RHLVSLQPAQ MHRFWRGLPL HLDSVDAVYE RTSDHKIVFF KGDRYWVFKD NNVEEGYPRP
   421  VSDFSLPPGG IDAAFSWAHN DRTYFFKDQL YWRYDDHTRH MDPGYPAQSP LWRGVPSTLD
   481  DAMRWSDGAS YFFRGQEYWK VLDGELEVAP GYPQSTARDW LVCGDSQADG SVAAGVDAAE
   541  GPRAPPGQHD QSRSEDGYEV CSCTSGASSP PGAPGPLVAA TMLLLLPPLS PGALWTAAQA
   601  LTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMP17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 50 nTPM
  • basal ganglia: 41 nTPM
  • cerebral cortex: 39 nTPM
  • amygdala: 27 nTPM
  • hypothalamus: 22 nTPM
  • ovary: 13 nTPM

Single-cell type

  • melanocytes: 87 nCPM
  • oligodendrocyte progenitor cells: 52 nCPM
  • brain excitatory neurons: 51 nCPM
  • brain inhibitory neurons: 51 nCPM
  • other brain neurons: 29 nCPM
  • thymocytes: 26 nCPM

Immune cell

  • memory B-cell: 0.5 nTPM
  • non-classical monocyte: 0.5 nTPM
  • classical monocyte: 0.4 nTPM
  • intermediate monocyte: 0.4 nTPM
  • naive B-cell: 0.3 nTPM
  • myeloid DC: 0.1 nTPM

Brain region

  • cerebral cortex: 96 nTPM
  • hippocampal formation: 90 nTPM
  • basal ganglia: 47 nTPM
  • amygdala: 43 nTPM
  • hypothalamus: 43 nTPM
  • white matter: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.07
gnomAD pLI
0
gnomAD missense Z
0.21
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMP17 as an antibody target. Whether an autoantibody or antibody against MMP17 could matter depends on whether native MMP17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMP17 is annotated at the cell surface, where native MMP17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MMP17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MMP17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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