MMP16

Protein identityUniProt · HPA

UniProt accession

P51512

Gene

MMP16

Ensembl

ENSG00000156103

Chromosome

8

Canonical length

607 aa

Protein class

Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Subcellular location

Vesicles,Cytosol

Secretome location

Secreted to extracellular matrix

OverviewNCBI Gene

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

607 residues, UniProt reviewed canonical sequence.

>P51512|MMP16
     1  MILLTFSTGR RLDFVHHSGV FFLQTLLWIL CATVCGTEQY FNVEVWLQKY GYLPPTDPRM
    61  SVLRSAETMQ SALAAMQQFY GINMTGKVDR NTIDWMKKPR CGVPDQTRGS SKFHIRRKRY
   121  ALTGQKWQHK HITYSIKNVT PKVGDPETRK AIRRAFDVWQ NVTPLTFEEV PYSELENGKR
   181  DVDITIIFAS GFHGDSSPFD GEGGFLAHAY FPGPGIGGDT HFDSDEPWTL GNPNHDGNDL
   241  FLVAVHELGH ALGLEHSNDP TAIMAPFYQY METDNFKLPN DDLQGIQKIY GPPDKIPPPT
   301  RPLPTVPPHR SIPPADPRKN DRPKPPRPPT GRPSYPGAKP NICDGNFNTL AILRREMFVF
   361  KDQWFWRVRN NRVMDGYPMQ ITYFWRGLPP SIDAVYENSD GNFVFFKGNK YWVFKDTTLQ
   421  PGYPHDLITL GSGIPPHGID SAIWWEDVGK TYFFKGDRYW RYSEEMKTMD PGYPKPITVW
   481  KGIPESPQGA FVHKENGFTY FYKGKEYWKF NNQILKVEPG YPRSILKDFM GCDGPTDRVK
   541  EGHSPPDDVD IVIKLDNTAS TVKAIAIVIP CILALCLLVL VYTVFQFKRK GTPRHILYCK
   601  RSMQEWV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMP16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

5.3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.35

gnomAD pLI

0.92

gnomAD missense Z

3.52

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chondrocyte proliferation
• collagen catabolic process
• craniofacial suture morphogenesis
• embryonic cranial skeleton morphogenesis
• endochondral ossification
• extracellular matrix organization
• protein processing
• proteolysis
• skeletal system development

Molecular functions

• enzyme activator activity
• metalloaminopeptidase activity
• metalloendopeptidase activity
• zinc ion binding

Cellular components

• cell surface
• extracellular matrix
• extracellular space
• Golgi lumen
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Hemopexin-like domain
• Peptidase M10, metallopeptidase
• Peptidoglycan binding-like
• Peptidase, metallopeptidase
• Hemopexin, conserved site
• Hemopexin-like repeats
• Peptidase M10A, cysteine switch, zinc binding site
• Peptidase M10A
• Peptidase M10A, matrix metallopeptidase, C-terminal
• Metallopeptidase, catalytic domain superfamily
• Peptidase M10A, catalytic domain
• PGBD-like superfamily
• Hemopexin-like domain superfamily
• Hemopexin
• Matrixin
• Putative peptidoglycan binding domain
• Domain of unknown function (DUF3377)

KeywordsUniProt

• Calcium
• Cell membrane
• Cleavage on pair of basic residues
• Collagen degradation
• Disulfide bond
• Extracellular matrix
• Glycoprotein
• Hydrolase
• Membrane
• Metal-binding
• Metalloprotease
• Protease
• Repeat
• Secreted
• Signal
• Transmembrane
• Transmembrane helix
• Zinc
• Zymogen

InteractionsUniProt · HPA

Protein binding partners of MMP16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CSPG4