MMP15

Protein identityUniProt · HPA

UniProt accession

P51511

Gene

MMP15

Ensembl

ENSG00000102996

Chromosome

16

Canonical length

669 aa

Protein class

Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

669 residues, UniProt reviewed canonical sequence.

>P51511|MMP15
     1  MGSDPSAPGR PGWTGSLLGD REEAARPRLL PLLLVLLGCL GLGVAAEDAE VHAENWLRLY
    61  GYLPQPSRHM STMRSAQILA SALAEMQRFY GIPVTGVLDE ETKEWMKRPR CGVPDQFGVR
   121  VKANLRRRRK RYALTGRKWN NHHLTFSIQN YTEKLGWYHS MEAVRRAFRV WEQATPLVFQ
   181  EVPYEDIRLR RQKEADIMVL FASGFHGDSS PFDGTGGFLA HAYFPGPGLG GDTHFDADEP
   241  WTFSSTDLHG NNLFLVAVHE LGHALGLEHS SNPNAIMAPF YQWKDVDNFK LPEDDLRGIQ
   301  QLYGTPDGQP QPTQPLPTVT PRRPGRPDHR PPRPPQPPPP GGKPERPPKP GPPVQPRATE
   361  RPDQYGPNIC DGDFDTVAML RGEMFVFKGR WFWRVRHNRV LDNYPMPIGH FWRGLPGDIS
   421  AAYERQDGRF VFFKGDRYWL FREANLEPGY PQPLTSYGLG IPYDRIDTAI WWEPTGHTFF
   481  FQEDRYWRFN EETQRGDPGY PKPISVWQGI PASPKGAFLS NDAAYTYFYK GTKYWKFDNE
   541  RLRMEPGYPK SILRDFMGCQ EHVEPGPRWP DVARPPFNPH GGAEPGADSA EGDVGDGDGD
   601  FGAGVNKDGG SRVVVQMEEV ARTVNVVMVL VPLLLLLCVL GLTYALVQMQ RKGAPRVLLY
   661  CKRSLQEWV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMP15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

51 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MMP15.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 144 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Developmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.48

gnomAD pLI

0.07

gnomAD missense Z

1.33

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• collagen catabolic process
• endodermal cell differentiation
• extracellular matrix disassembly
• extracellular matrix organization
• protein modification process
• proteolysis
• response to estradiol

Molecular functions

• enzyme activator activity
• metalloaminopeptidase activity
• metalloendopeptidase activity
• zinc ion binding

Cellular components

• extracellular matrix
• extracellular space
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Hemopexin-like domain
• Peptidase M10, metallopeptidase
• Peptidoglycan binding-like
• Peptidase, metallopeptidase
• Hemopexin, conserved site
• Hemopexin-like repeats
• Peptidase M10A, cysteine switch, zinc binding site
• Peptidase M10A
• Peptidase M10A, matrix metallopeptidase, C-terminal
• Metallopeptidase, catalytic domain superfamily
• Peptidase M10A, catalytic domain
• PGBD-like superfamily
• Hemopexin-like domain superfamily
• Hemopexin
• Matrixin
• Putative peptidoglycan binding domain
• Domain of unknown function (DUF3377)

KeywordsUniProt

• Calcium
• Cleavage on pair of basic residues
• Disulfide bond
• Glycoprotein
• Hydrolase
• Membrane
• Metal-binding
• Metalloprotease
• Phosphoprotein
• Protease
• Repeat
• Signal
• Transmembrane
• Transmembrane helix
• Zinc
• Zymogen