Seroatlas · Human Serome Atlas

MLDHR

PTEN upstream open reading frame MP31

Also known as: ENSG00000289051, MP31_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C0HLV8
Gene
MLDHR
Ensembl
ENSG00000289051
Chromosome
10
Canonical length
31 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables L-lactate dehydrogenase inhibitor activity. Involved in negative regulation of oxidative phosphorylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

31 residues, UniProt reviewed canonical sequence.

>C0HLV8|MLDHR
     1  MWRDSLCAAA GYALGAGTRL RSVLSSRKLQ P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MLDHR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
0.6 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 0.6 nTPM
  • placenta: 0.6 nTPM
  • fallopian tube: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • appendix: 0 nTPM
  • bone marrow: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • neutrophil: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

  • L-lactate dehydrogenase inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • PTEN upstream open reading frame MP31
  • PTEN upstream open reading frame MP31

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MLDHR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MLDHR as an antibody target. Whether an autoantibody or antibody against MLDHR could matter depends on whether native MLDHR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MLDHR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MLDHR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MLDHR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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