Seroatlas · Human Serome Atlas

MKRN4P

Putative E3 ubiquitin-protein ligase makorin-4

Also known as: MKRN4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13434
Gene: MKRN4P
Canonical length: 485 aa

OverviewNCBI Gene

No narrative summary is available for MKRN4P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q13434|MKRN4P
     1  MAEAAAPGTT VTTSGAGAAA AEAAETAEAV SPTPIPTVTA PSPRAGGGVG GSDGSDGSGG
    61  RGDSGAYDGS GACGGSDACD GSGDSSGDSW TKQVTCRYFK YGICKEGDNC RYSHDLSDRL
   121  CGVVCKYFQR GCCVYGDRCR CEHSKPLKQE EATATELTTK SSLAASSSLS SIVGPLVEMN
   181  TNEAESRNSN FATVVAGSED WANAIEFVPG QPYCGRTVPS CTEAPLQGSV TKEESEEEQT
   241  AVETKKQLCP YAAVGQCRYG ENCVYLHGDL CDMCGLQVLH PMDAAQRSQH IQACIEAHEK
   301  DMEFSFAVQR SKDKVCGICM EVVYEKANPN EHRFGILSNC NHTFCLKCIR KWRSAKEFES
   361  RIVKSCPQCR ITSNFVIPSE YWVEEKEEKQ KLIQKYKEAM SNKACKYFDE GRGSCPFGEN
   421  CFYKHMYPDG RREEPQRQQV GTSSRNPGQQ RNHFWEFFEE GANSNPFDDE EEAVTFELGE
   481  MLLML

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MKRN4P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MKRN4P as an antibody target. Whether an autoantibody or antibody against MKRN4P could matter depends on whether native MKRN4P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MKRN4P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MKRN4P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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