MGLL

Protein identityUniProt · HPA

UniProt accession

Q99685

Gene

MGLL

Ensembl

ENSG00000074416

Chromosome

3

Canonical length

303 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Vesicles

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q99685|MGLL
     1  MPEESSPRRT PQSIPYQDLP HLVNADGQYL FCRYWKPTGT PKALIFVSHG AGEHSGRYEE
    61  LARMLMGLDL LVFAHDHVGH GQSEGERMVV SDFHVFVRDV LQHVDSMQKD YPGLPVFLLG
   121  HSMGGAIAIL TAAERPGHFA GMVLISPLVL ANPESATTFK VLAAKVLNLV LPNLSLGPID
   181  SSVLSRNKTE VDIYNSDPLI CRAGLKVCFG IQLLNAVSRV ERALPKLTVP FLLLQGSADR
   241  LCDSKGAYLL MELAKSQDKT LKIYEGAYHV LHKELPEVTN SVFHEINMWV SQRTATAGTA
   301  SPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MGLL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

161 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.79

gnomAD pLI

0.02

gnomAD missense Z

1.07

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• acylglycerol catabolic process
• arachidonate metabolic process
• fatty acid biosynthetic process
• inflammatory response
• lipid metabolic process
• monoacylglycerol catabolic process
• regulation of endocannabinoid signaling pathway
• regulation of inflammatory response
• regulation of sensory perception of pain
• regulation of signal transduction
• triglyceride catabolic process

Molecular functions

• monoacylglycerol lipase activity
• phosphatidylcholine lysophospholipase activity
• protein homodimerization activity

Cellular components

• cytosol
• endoplasmic reticulum membrane
• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Alpha/beta hydrolase fold-1
• Alpha/beta hydrolase domain-containing protein 17C-like
• Alpha/Beta hydrolase fold
• Serine aminopeptidase, S33
• Monoacylglycerol and Diacylglycerol Lipase

KeywordsUniProt

• Cytoplasm
• Fatty acid biosynthesis
• Fatty acid metabolism
• Hydrolase
• Lipid biosynthesis
• Lipid degradation
• Lipid metabolism
• Membrane
• Nitration
• Phosphoprotein
• Serine esterase

InteractionsUniProt · HPA

Protein binding partners of MGLL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ADRB2