Seroatlas · Human Serome Atlas

MGARP

Protein MGARP

Also known as: C4orf49, CESP-1, HUMMR, HUMMR_HUMAN, OSAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDB4
Gene: MGARP
Ensembl: ENSG00000137463
Chromosome: 4
Canonical length: 240 aa
Protein class: Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in several processes, including axonal transport; cellular response to gonadotropin-releasing hormone; and nervous system development. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q8TDB4|MGARP
     1  MYLRRAVSKT LALPLRAPPN PAPLGKDASL RRMSSNRFPG SSGSNMIYYL VVGVTVSAGG
    61  YYAYKTVTSD QAKHTEHKTN LKEKTKAEIH PFQGEKENVA ETEKASSEAP EELIVEAEVV
   121  DAEESPSATV VVIKEASACP GHVEAAPETT AVSAETGPEV TDAAARETTE VNPETTPEVT
   181  NAALDEAVTI DNDKDTTKNE TSDEYAELEE ENSPAESESS AGDDLQEEAS VGSEAASAQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MGARP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 215 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 215 nTPM
retina: 108 nTPM
ovary: 34 nTPM
cerebellum: 16 nTPM
pituitary gland: 12 nTPM
adipose tissue: 9.8 nTPM

Single-cell type

ocular epithelial cells: 409 nCPM
müller glia: 353 nCPM
adrenal cortex cells: 120 nCPM
retinal horizontal cells: 100 nCPM
granulosa cells: 78 nCPM
retinal bipolar cells: 77 nCPM

Immune cell

memory CD4 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebellum: 12 nTPM
midbrain: 3.8 nTPM
hypothalamus: 3.7 nTPM
medulla oblongata: 3.2 nTPM
pons: 3.1 nTPM
cerebral cortex: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein MGARP
Protein MGARP, N-terminal
Mitochondria Localisation Sequence

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MGARP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RHOT2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MGARP as an antibody target. Whether an autoantibody or antibody against MGARP could matter depends on whether native MGARP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MGARP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MGARP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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