Seroatlas · Human Serome Atlas

MFSD9

Major facilitator superfamily domain-containing protein 9

Also known as: MFSD9_HUMAN, MGC11332

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBP5
Gene: MFSD9
Ensembl: ENSG00000135953
Chromosome: 2
Canonical length: 474 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoli,Nucleoli rim

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>Q8NBP5|MFSD9
     1  MELGGHWDMN SAPRLVSETA ERKQEQKTGT EAEAADSGAV GARRFLLCLY LVGFLDLFGV
    61  SMVVPLLSLH VKSLGASPTV AGIVGSSYGI LQLFSSTLVG CWSDVVGRRS SLLACILLSA
   121  LGYLLLGAAT NVFLFVLARV PAGIFKHTLS ISRALLSDVV PEKERPLVIG HFNTASGVGF
   181  ILGPVVGGYL TELEDGFYLT AFICFLVFIL NAGLVWFFPW REAKPGSTEK GLPLRKTHVL
   241  LGRSHDTVQE AATSRRARAS KKTAQPWVEV VLALRNMKNL LFSEMWDIFL VRLLMAMAVM
   301  LYYSNFVLAL EERFGVRPKV TGYLISYSSM LGAVAGLALG PILRLYKHNS QALLLHSSIL
   361  TCTLLLLYSL APTMGAVVLS STLLSFSTAI GRTCITDLQL TVGGAQASGT LIGVGQSVTA
   421  VGRIIAPLLS GVAQEVSPCG PPSLGAVLAL VAIFIMSLNK RHSSGDGNSK LKSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

liver: 11 nTPM
pancreas: 9 nTPM
duodenum: 8.2 nTPM
cerebellum: 6.8 nTPM
small intestine: 6.8 nTPM
colon: 6 nTPM

Single-cell type

somatotrophs: 28 nCPM
breast lactating cells: 27 nCPM
pancreatic acinar cells: 27 nCPM
esophageal apical cells: 26 nCPM
neutrophil progenitors: 25 nCPM
thyrotrophs: 24 nCPM

Immune cell

eosinophil: 1.5 nTPM
basophil: 1.3 nTPM
gdT-cell: 1.2 nTPM
plasmacytoid DC: 1.2 nTPM
naive CD8 T-cell: 1.1 nTPM
neutrophil: 1 nTPM

Brain region

cerebellum: 8.6 nTPM
cerebral cortex: 3.7 nTPM
hippocampal formation: 3.7 nTPM
choroid plexus: 3.4 nTPM
hypothalamus: 3.2 nTPM
thalamus: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -0.8
DepMap mean gene effect: 0.01
DepMap dependency class: selective

OntologyGO

Molecular functions

transmembrane transporter activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD9 as an antibody target. Whether an autoantibody or antibody against MFSD9 could matter depends on whether native MFSD9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MFSD9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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